MELK-8a structure
|
Common Name | MELK-8a | ||
---|---|---|---|---|
CAS Number | 1922153-17-0 | Molecular Weight | 432.572 | |
Density | N/A | Boiling Point | N/A | |
Molecular Formula | C25H32N6O | Melting Point | N/A | |
MSDS | N/A | Flash Point | N/A |
Use of MELK-8aMELK-8a (NVS-MELK8a) is a highly potent and selective maternal embryonic leucine zipper kinase (MELK) inhibitor with IC50 of 2 nM. MELK-8a also inhibits Flt3 (ITD), Haspin, PDGFRα with IC50s of 0.18, 0.19, and 0.42 μM, respectively. MELK plays an essential role in regulating cell mitosis in a subset of cancer cells[1]. |
Name | MELK-8a |
---|---|
Synonym | More Synonyms |
Description | MELK-8a (NVS-MELK8a) is a highly potent and selective maternal embryonic leucine zipper kinase (MELK) inhibitor with IC50 of 2 nM. MELK-8a also inhibits Flt3 (ITD), Haspin, PDGFRα with IC50s of 0.18, 0.19, and 0.42 μM, respectively. MELK plays an essential role in regulating cell mitosis in a subset of cancer cells[1]. |
---|---|
Related Catalog | |
References |
Molecular Formula | C25H32N6O |
---|---|
Molecular Weight | 432.572 |
Exact Mass | 432.264 |
1-methyl-4-[4-[4-[3-(piperidin-4-ylmethoxy)pyridin-4-yl]pyrazol-1-yl]phenyl]piperazine |