1432913-36-4

1432913-36-4 structure

Name: GX-674
Chemical Name: GX674
CAS Number: 1432913-36-4
Molecular Formula: C₂₁H₁₃ClF₂N₆O₃S₂
Molecular Weight: 534.9
Catalog: Signaling Pathways Membrane Transporter/Ion Channel Sodium Channel
Create Date: 2018-02-15 01:24:35
Modify Date: 2026-07-14 23:11:18
GX-674 is a potent, state-dependent, isoform-selective voltage-gated sodium channel 1.7 (Nav1.7) antagonist with an IC50 of 0.1 nM at -40 mV[1].

Name	GX674

Description	GX-674 is a potent, state-dependent, isoform-selective voltage-gated sodium channel 1.7 (Nav1.7) antagonist with an IC50 of 0.1 nM at -40 mV[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel Research Areas >> Cardiovascular Disease Research Areas >> Neurological Disease
Target	hNav1.7:0.1 nM (IC50)
References	[1]. Ahuja S, et al. Structural basis of Nav1.7 inhibition by an isoform-selective small-molecule antagonist. Science. 2015 Dec 18;350(6267):aac5464.