DC Chemicals Limited
China
Product Name: BGB-3111
Price: $900.0/100mg $1800.0/250mg $3600.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 7-(1-acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

1633350-06-7

1633350-06-7 structure

1633350-06-7 structure

Name: (±)-Zanubrutinib
Chemical Name: BGB-3111
CAS Number: 1633350-06-7
Molecular Formula: C₂₇H₂₉N₅O₃
Molecular Weight: 471.551
Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK Btk
Create Date: 2018-03-16 10:52:59
Modify Date: 2024-01-14 10:21:58
(±)-Zanubrutinib is a potent, selective and orally available Bruton's tyrosine kinase (Btk) inhibitor.

Name	BGB-3111
Synonyms	Pyrazolo[1,5-a]pyrimidine-3-carboxamide, 4,5,6,7-tetrahydro-7-[1-(1-oxo-2-propen-1-yl)-4-piperidinyl]-2-(4-phenoxyphenyl)- 7-(1-Acryloyl-4-piperidinyl)-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide

Description	(±)-Zanubrutinib is a potent, selective and orally available Bruton's tyrosine kinase (Btk) inhibitor.
Related Catalog	Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Btk Research Areas >> Cancer
In Vitro	In both biochemical and cellular assays, (±)-Zanubrutinib demonstrates nanomolar Btk inhibition activity. In several MCL and DLBCL cell lines, (±)-Zanubrutinib inhibits BCR aggregation-triggered Btk autophosphorylation, blocks downstream PLC-γ2 signaling, and potently inhibits cell proliferation. In comparison with ibrutinib, (±)-Zanubrutinib shows much more restricted off-target activities against a panel of kinases, including ITK. (±)-Zanubrutinib is at least 10-fold weaker than ibrutinib in inhibiting rituximab induced ADCC, consistent with its weak ITK inhibition activity[1].
In Vivo	(±)-Zanubrutinib induces dose-dependent anti-tumor effects against REC-1 MCL xenografts engrafted either subcutaneously or systemically via tail vein injection in mice. In the subcutaneous xenografts. Preliminary 14-day toxicity study in rats shows that (±)-Zanubrutinib is very well tolerated and maximal tolerate dose (MTD) is not reached when it is dosed up to 250mg/kg/day[1].
References	[1]. Na L, et al. BGB-3111 is a novel and highly selective Bruton's tyrosine kinase (BTK) inhibitor. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 2597. doi:10.1158/1538-7445.AM2015-2597

Density	1.3±0.1 g/cm3
Boiling Point	713.4±60.0 °C at 760 mmHg
Molecular Formula	C₂₇H₂₉N₅O₃
Molecular Weight	471.551
Flash Point	385.2±32.9 °C
Exact Mass	471.227051
LogP	3.64
Vapour Pressure	0.0±2.3 mmHg at 25°C
Index of Refraction	1.680