DC Chemicals Limited
China
Product Name: THK5351
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Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

1707147-26-9

1707147-26-9 structure

1707147-26-9 structure

Name: THK5351
Chemical Name: THK5351
CAS Number: 1707147-26-9
Molecular Formula: C₁₈H₁₈FN₃O₂
Molecular Weight: 327.353
Catalog: Biochemical Assay Reagents
Create Date: 2018-01-24 16:02:44
Modify Date: 2024-01-06 14:24:38
THK5351 can be radiolabeled and used as a radiotracer for in vivo imaging of tau pathology in the brain.

Name	THK5351
Synonyms	(2S)-1-Fluoro-3-({2-[6-(methylamino)-3-pyridinyl]-6-quinolinyl}oxy)-2-propanol 2-Propanol, 1-fluoro-3-[[2-[6-(methylamino)-3-pyridinyl]-6-quinolinyl]oxy]-, (2S)-

Description	THK5351 can be radiolabeled and used as a radiotracer for in vivo imaging of tau pathology in the brain.
Related Catalog	Signaling Pathways >> Others >> Others Biochemical Assay Reagents Research Areas >> Neurological Disease
In Vitro	Aggregated tau protein is a major neuropathological substrate central to the pathophysiology of neurodegenerative diseases such as Alzheimer's disease (AD). 18F-THK5351 binds to Alzheimer disease hippocampal homogenates with high affinity (Kd=2.9 nM; maximum number of binding sites=368.3 pmol/g tissue). It has fast dissociation from white-matter tissue. The THK5351 binding amount correlates with the amount of tau deposits in tissue[1].
In Vivo	THK5351 exhibits favorable pharmacokinetics and no defluorination in mice. 18F-THK5351 enters the brain immediately after intravenous injection and shows a fast washout from the brain. At 0.1 and 1 mg/kg, no animals died and no treatment-related changes in any animal are noted in clinical observations, body weight measurement, and pathologic examination[1]. Autoradiography in the brain sections of patients with PSP demonstrates [3H]THK-5351 binding to tau deposits with a high selectivity. Although patients with PSP exhibits no remarkable [18F]THK-5351 retention in the temporal cortex, significantly higher tracer retention is observed in the globus pallidus and midbrain[2].
References	[1]. Harada R, et al. 18F-THK5351: A Novel PET Radiotracer for Imaging Neurofibrillary Pathology in Alzheimer Disease. J Nucl Med. 2016 Feb;57(2):208-14. [2]. Ishiki A, et al. Tau imaging with [18 F]THK-5351 in progressive supranuclear palsy. Eur J Neurol. 2017 Jan;24(1):130-136.

Density	1.3±0.1 g/cm3
Boiling Point	561.5±50.0 °C at 760 mmHg
Molecular Formula	C₁₈H₁₈FN₃O₂
Molecular Weight	327.353
Flash Point	293.4±30.1 °C
Exact Mass	327.138306
LogP	2.65
Vapour Pressure	0.0±1.6 mmHg at 25°C
Index of Refraction	1.642
Storage condition	-20℃