864864-86-8

864864-86-8 structure

Name: DFMTI
Chemical Name: DFMTI
CAS Number: 864864-86-8
Molecular Formula: C₂₀H₁₈F₂N₄O
Molecular Weight: 368.380
Catalog: Research Areas Cancer
Create Date: 2018-03-18 13:11:46
Modify Date: 2024-02-04 08:01:51
DFMTI can completely block the rmGlu1 L757V glutamate response.In vitro: DFMTI can completely block the rmGlu1 L757V glutamate response, although significantly higher concentrations were required to induce blockade.In vivo: DFMTI is efficacious in disrupting prepulse inhibition when dosed orally in rats. DFMTI exhibits a moderate decrease in human potency of approximately 3-fold when compared to rat, exemplified by DFMTI.

Name	DFMTI
Synonyms	1H-Isoindol-1-one, 5-[1-(2,4-difluorophenyl)-5-methyl-1H-1,2,3-triazol-4-yl]-2,3-dihydro-2-(1-methylethyl)- 5-[1-(2,4-Difluorophenyl)-5-methyl-1H-1,2,3-triazol-4-yl]-2-isopropyl-1-isoindolinone

Description	DFMTI can completely block the rmGlu1 L757V glutamate response.In vitro: DFMTI can completely block the rmGlu1 L757V glutamate response, although significantly higher concentrations were required to induce blockade.In vivo: DFMTI is efficacious in disrupting prepulse inhibition when dosed orally in rats. DFMTI exhibits a moderate decrease in human potency of approximately 3-fold when compared to rat, exemplified by DFMTI.
Related Catalog	Research Areas >> Cancer
References	[1]. Cho HP et al. A novel class of succinimide-derived negative allosteric modulators of metabotropic glutamate receptor subtype 1 provides insight into a disconnect in activity between the rat and human receptors. ACS Chem Neurosci. 2014 Jul 16;5(7):597-610.