DFMTI

Modify Date: 2024-02-04 08:01:51

DFMTI Structure
DFMTI structure
Common Name DFMTI
CAS Number 864864-86-8 Molecular Weight 368.380
Density 1.4±0.1 g/cm3 Boiling Point 545.1±60.0 °C at 760 mmHg
Molecular Formula C20H18F2N4O Melting Point N/A
MSDS N/A Flash Point 283.5±32.9 °C

 Use of DFMTI


DFMTI can completely block the rmGlu1 L757V glutamate response.In vitro: DFMTI can completely block the rmGlu1 L757V glutamate response, although significantly higher concentrations were required to induce blockade.In vivo: DFMTI is efficacious in disrupting prepulse inhibition when dosed orally in rats. DFMTI exhibits a moderate decrease in human potency of approximately 3-fold when compared to rat, exemplified by DFMTI.

 Names

Name DFMTI
Synonym More Synonyms

 DFMTI Biological Activity

Description DFMTI can completely block the rmGlu1 L757V glutamate response.In vitro: DFMTI can completely block the rmGlu1 L757V glutamate response, although significantly higher concentrations were required to induce blockade.In vivo: DFMTI is efficacious in disrupting prepulse inhibition when dosed orally in rats. DFMTI exhibits a moderate decrease in human potency of approximately 3-fold when compared to rat, exemplified by DFMTI.
Related Catalog
References

[1]. Cho HP et al. A novel class of succinimide-derived negative allosteric modulators of metabotropic glutamate receptor subtype 1 provides insight into a disconnect in activity between the rat and human receptors. ACS Chem Neurosci. 2014 Jul 16;5(7):597-610.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 545.1±60.0 °C at 760 mmHg
Molecular Formula C20H18F2N4O
Molecular Weight 368.380
Flash Point 283.5±32.9 °C
Exact Mass 368.144867
LogP 3.00
Vapour Pressure 0.0±1.5 mmHg at 25°C
Index of Refraction 1.645

 Synonyms

1H-Isoindol-1-one, 5-[1-(2,4-difluorophenyl)-5-methyl-1H-1,2,3-triazol-4-yl]-2,3-dihydro-2-(1-methylethyl)-
5-[1-(2,4-Difluorophenyl)-5-methyl-1H-1,2,3-triazol-4-yl]-2-isopropyl-1-isoindolinone
Top Suppliers:I want be here
  • DC Chemicals Limited
  • China
  • Product Name: DFMTI
  • Price: $280.0/5mg $400.0/10mg $1200.0/50mg
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao

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DFMTI suppliers


Price: $340/10mM*1mLinDMSO

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