1135688-15-1

1135688-15-1 structure

Name: Biotin-VAD-FMK
Chemical Name: Biotin-VAD-FMK
CAS Number: 1135688-15-1
Molecular Formula: C₃₀H₄₉FN₆O₈S
Molecular Weight: 672.81
Catalog: Biochemical Assay Reagents
Create Date: 2018-04-02 09:26:26
Modify Date: 2024-01-10 20:31:31
Biotin-VAD-FMK is a cell permeable, irreversible biotin-labeled caspase inhibitor, used to identify active caspases in cell lysates.

Name	Biotin-VAD-FMK

Description	Biotin-VAD-FMK is a cell permeable, irreversible biotin-labeled caspase inhibitor, used to identify active caspases in cell lysates.
Related Catalog	Signaling Pathways >> Apoptosis >> Caspase Biochemical Assay Reagents Research Areas >> Cancer
Target	Caspase
In Vitro	Biotin-VAD-FMK is a synthetic peptide designed as a methyl ester to facilitate cell permeability.
In Vivo	To examine whether caspase-2 is activated in the absence of proteolytic cleavage, an in vivo affinity labeling approach is used, using the biotinylated caspase inhibitor biotin-VAD-fmk that detects only active caspases[2].
References	[1]. Li J, et al. Nitric oxide suppresses apoptosis via interrupting caspase activation and mitochondrial dysfunction in cultured hepatocytes. J Biol Chem. 1999 Jun 11;274(24):17325-33. [2]. Samraj AK, et al. Loss of caspase-9 reveals its essential role for caspase-2 activation and mitochondrial membranedepolarization. Mol Biol Cell. 2007 Jan;18(1):84-93.