355140-49-7

355140-49-7 structure

Name: Ac-Nle-Pro-Nle-Asp-AMC
Chemical Name: Ac-Nle-Pro-Nle-Asp-AMC
CAS Number: 355140-49-7
Molecular Formula: C₃₃H₄₅N₅O₉
Molecular Weight: 655.739
Catalog: Signaling Pathways Metabolic Enzyme/Protease Proteasome
Create Date: 2018-01-03 04:50:06
Modify Date: 2026-08-17 19:14:28
Ac-Nle-Pro-Nle-Asp-AMC is a specific substrate for 26S proteasome. Ac-Nle-Pro-Nle-Asp-AMC can be used for the 26S proteasome caspase-like activity analysis[1][2][3].

Name	Ac-Nle-Pro-Nle-Asp-AMC
Synonyms	AC-NLE-PRO-NLE-ASP-AMC (3S)-4-Hydroxy-3-({(2S)-1-hydroxy-2-[(hydroxy{(2S)-1-[N-(1-hydroxyethylidene)-L-norleucyl]-2-pyrrolidinyl}methylene)amino]hexylidene}amino)-4-[(4-methyl-2-oxo-2H-chromen-7-yl)imino]butanoic acid AC-NLE-PRO-NLE-ASP-MCA L-α-Aspagine, N-acetyl-L-norleucyl-L-prolyl-L-norleucyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl) N-Acetyl-L-norleucyl-L-prolyl-L-norleucyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-L-α-aspagine (S)-3-((S)-2-((S)-1-((S)-2-Acetamidohexanoyl)pyrrolidine-2-cboxamido)hexanamido)-4-((4-methyl-2-oxo-2H-chromen-7-yl)amino)-4-oxobutanoic acid

Description	Ac-Nle-Pro-Nle-Asp-AMC is a specific substrate for 26S proteasome. Ac-Nle-Pro-Nle-Asp-AMC can be used for the 26S proteasome caspase-like activity analysis[1][2][3].
Related Catalog	Research Areas >> Others Signaling Pathways >> Metabolic Enzyme/Protease >> Proteasome
References	[1]. Dunlop RA, et al. The impact of specific oxidized amino acids on protein turnover in J774 cells. Biochem J. 2008 Feb 15;410(1):131-40. [2]. Kirk-Ballard H, et al. An extract of Artemisia dracunculus L. inhibits ubiquitin-proteasome activity and preserves skeletal muscle mass in a murine model of diabetes. PLoS One. 2013;8(2):e57112. [3]. Pakavathkumar P, et al. Methylene Blue Inhibits Caspases by Oxidation of the Catalytic Cysteine. Sci Rep. 2015 Sep 24;5:13730.