355140-49-7

355140-49-7 structure

Name: Ac-Nle-Pro-Nle-Asp-AMC
Chemical Name: Ac-Nle-Pro-Nle-Asp-AMC
CAS Number: 355140-49-7
Molecular Formula: C₃₃H₄₅N₅O₉
Molecular Weight: 655.739
Catalog: Signaling Pathways Metabolic Enzyme/Protease Proteasome
Create Date: 2018-01-03 04:50:06
Modify Date: 2025-08-24 19:22:35
Ac-Nle-Pro-Nle-Asp-AMC is a specific substrate for 26S proteasome. Ac-Nle-Pro-Nle-Asp-AMC can be used for the 26S proteasome caspase-like activity analysis[1][2][3].

Name	Ac-Nle-Pro-Nle-Asp-AMC
Synonyms	(3S)-4-Hydroxy-3-({(2S)-1-hydroxy-2-[(hydroxy{(2S)-1-[N-(1-hydroxyethylidene)-L-norleucyl]-2-pyrrolidinyl}methylene)amino]hexylidene}amino)-4-[(4-methyl-2-oxo-2H-chromen-7-yl)imino]butanoic acid Butanoic acid, 4-hydroxy-3-[[(2S)-1-hydroxy-2-[[hydroxy[(2S)-1-[(2S)-2-[(1-hydroxyethylidene)amino]-1-oxohexyl]-2-pyrrolidinyl]methylene]amino]hexylidene]amino]-4-[(4-methyl-2-oxo-2H-1-benzopyran-7-yl)imino]-, (3S)-

Description	Ac-Nle-Pro-Nle-Asp-AMC is a specific substrate for 26S proteasome. Ac-Nle-Pro-Nle-Asp-AMC can be used for the 26S proteasome caspase-like activity analysis[1][2][3].
Related Catalog	Research Areas >> Others Signaling Pathways >> Metabolic Enzyme/Protease >> Proteasome
References	[1]. Dunlop RA, et al. The impact of specific oxidized amino acids on protein turnover in J774 cells. Biochem J. 2008 Feb 15;410(1):131-40. [2]. Kirk-Ballard H, et al. An extract of Artemisia dracunculus L. inhibits ubiquitin-proteasome activity and preserves skeletal muscle mass in a murine model of diabetes. PLoS One. 2013;8(2):e57112. [3]. Pakavathkumar P, et al. Methylene Blue Inhibits Caspases by Oxidation of the Catalytic Cysteine. Sci Rep. 2015 Sep 24;5:13730.