357952-09-1

357952-09-1 structure

Name: Urocortin III (human) trifluoroacetate salt
Chemical Name: Urocortin III, human
CAS Number: 357952-09-1
Molecular Formula: C₁₈₅H₃₀₇N₅₃O₅₀S₂
Molecular Weight:
Catalog: Signaling Pathways GPCR/G Protein CRFR
Create Date: 2018-04-11 17:16:47
Modify Date: 2024-01-07 12:54:00
Urocortin III (human) is a corticotropin-releasing factor (CRF)-related peptide. Urocortin III (human) preferentially binds and activates CRF-R2 and has a discrete central nervous system and peripheral distribution. Urocortin III (human) selectively binds to type 2 CRF receptors with Ki values of 13.5, 21.7, and >100 nM for mCRF2β, rCRF2α, and hCRF1, respectively. Urocortin III (human) mediates somatostatin-dependent negative feedback control of Insulin (human) (HY-P0035) secretion[1][2].

Name	Urocortin III, human

Description	Urocortin III (human) is a corticotropin-releasing factor (CRF)-related peptide. Urocortin III (human) preferentially binds and activates CRF-R2 and has a discrete central nervous system and peripheral distribution. Urocortin III (human) selectively binds to type 2 CRF receptors with Ki values of 13.5, 21.7, and >100 nM for mCRF2β, rCRF2α, and hCRF1, respectively. Urocortin III (human) mediates somatostatin-dependent negative feedback control of Insulin (human) (HY-P0035) secretion[1][2].
Related Catalog	Research Areas >> Cardiovascular Disease Research Areas >> Endocrinology Signaling Pathways >> GPCR/G Protein >> CRFR Research Areas >> Neurological Disease
Target	Ki: 13.5 (mCRF2β), 21.7 (rCRF2α), and >100 nM ( hCRF1)[1]
In Vitro	Urocortin III (human) (20 分钟；稳定表达克隆人 CRF-R1 或鼠 CRF-R2 的 CHO 细胞) 诱导细胞内 cAMP 积累[1]。
References	[1]. Lewis K, et, al. Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor. Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7570-5. [2]. van der Meulen T, et, al. Urocortin3 mediates somatostatin-dependent negative feedback control of insulin secretion. Nat Med. 2015 Jul;21(7):769-76.

Molecular Formula	C₁₈₅H₃₀₇N₅₃O₅₀S₂