Urocortin III (human) trifluoroacetate salt

Modify Date: 2024-01-07 12:54:00

Urocortin III (human) trifluoroacetate salt structure	Common Name	Urocortin III (human) trifluoroacetate salt
	CAS Number	357952-09-1	Molecular Weight	N/A
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₈₅H₃₀₇N₅₃O₅₀S₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Urocortin III (human) trifluoroacetate salt

Urocortin III (human) is a corticotropin-releasing factor (CRF)-related peptide. Urocortin III (human) preferentially binds and activates CRF-R2 and has a discrete central nervous system and peripheral distribution. Urocortin III (human) selectively binds to type 2 CRF receptors with Ki values of 13.5, 21.7, and >100 nM for mCRF2β, rCRF2α, and hCRF1, respectively. Urocortin III (human) mediates somatostatin-dependent negative feedback control of Insulin (human) (HY-P0035) secretion[1][2].

Name	Urocortin III, human

Description	Urocortin III (human) is a corticotropin-releasing factor (CRF)-related peptide. Urocortin III (human) preferentially binds and activates CRF-R2 and has a discrete central nervous system and peripheral distribution. Urocortin III (human) selectively binds to type 2 CRF receptors with Ki values of 13.5, 21.7, and >100 nM for mCRF2β, rCRF2α, and hCRF1, respectively. Urocortin III (human) mediates somatostatin-dependent negative feedback control of Insulin (human) (HY-P0035) secretion[1][2].
Related Catalog	Research Areas >> Cardiovascular Disease Research Areas >> Endocrinology Signaling Pathways >> GPCR/G Protein >> CRFR Research Areas >> Neurological Disease
Target	Ki: 13.5 (mCRF2β), 21.7 (rCRF2α), and >100 nM ( hCRF1)[1]
In Vitro	Urocortin III (human) (20 分钟；稳定表达克隆人 CRF-R1 或鼠 CRF-R2 的 CHO 细胞) 诱导细胞内 cAMP 积累[1]。
References	[1]. Lewis K, et, al. Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor. Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7570-5. [2]. van der Meulen T, et, al. Urocortin3 mediates somatostatin-dependent negative feedback control of insulin secretion. Nat Med. 2015 Jul;21(7):769-76.

Molecular Formula	C₁₈₅H₃₀₇N₅₃O₅₀S₂

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: UROCORTIN III (HUMAN)
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Taiwan Oyi peptide Co. Ltd
China
Product Name: UROCORTIN III (HUMAN)
Price: $Inquiry/1mg $Inquiry/100kg
Purity: 98.0%
Delivery: 1 Day
Contact: Vinnie
Email: Jamie@api-made.com

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