GL Biochem (Shanghai) Ltd.
China
Product Name: Ac-Leu-Glu-His-Asp-chloromethylketone
Price: $Inquiry/1kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Jackie Yang

DC Chemicals Limited
China
Product Name: Caspase-9 Inhibitor III(Ac-LEHD-CMK)
Price: $950.0/50mg $1600.0/100mg $3000.0/250mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

403848-57-7

403848-57-7 structure

403848-57-7 structure

Name: Caspase-9 Inhibitor III
Chemical Name: Ac-Leu-Glu-His-Asp-chloromethylketone
CAS Number: 403848-57-7
Molecular Formula: C₂₄H₃₅ClN₆O₉
Molecular Weight: 587.02
Catalog: Signaling Pathways Apoptosis Caspase
Create Date: 2018-05-21 08:00:00
Modify Date: 2024-01-02 18:18:58
Caspase-9 Inhibitor III (Ac-LEHD-cmk) is a caspase-9 inhibitor. Caspase-9 Inhibitor III exhibits protective effects on ischemia-reperfusion-induced myocardial injury[1].

Name	Ac-Leu-Glu-His-Asp-chloromethylketone
Synonyms	Caspase-9 Inhibitor III AC-LEHD-CMK

Description	Caspase-9 Inhibitor III (Ac-LEHD-cmk) is a caspase-9 inhibitor. Caspase-9 Inhibitor III exhibits protective effects on ischemia-reperfusion-induced myocardial injury[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Apoptosis >> Caspase
Target	Caspase-9
In Vitro	Caspase-9 Inhibitor III (0.07-0.105 μM; 灌注 10 min) 显着减弱 I/R 诱导的离体大鼠心脏梗塞大小的增加，冠状动脉废水中乳酸脱氢酶的释放和肌酸激酶的释放，以及凋亡指数[1]。 Caspase-9 Inhibitor III (30 μM) 抑制由 MMP-2 诱导的肌钙蛋白 I 水解[2]。
References	[1]. Sodhi RK, et, al. Protective effects of caspase-9 and poly(ADP-ribose) polymerase inhibitors on ischemia-reperfusion-induced myocardial injury. Arch Pharm Res. 2009 Jul;32(7):1037-43. [2]. Castro MM, et, al. Inhibitory effects of caspase inhibitors on the activity of matrix metalloproteinase-2. Biochem Pharmacol. 2013 Aug 15;86(4):469-75.

Molecular Formula	C₂₄H₃₅ClN₆O₉
Molecular Weight	587.02