132956-87-7
132956-87-7 structure
- Name: (Arg6,β-cyclohexyl-Ala8,D-Tic16,Arg17,Cys18)-Atrial Natriuretic Factor (6-18) amide (mouse, rabbit, rat) trifluoroacetate salt
- Chemical Name: A 71915
- CAS Number: 132956-87-7
- Molecular Formula: C69H116N26O15S2
- Molecular Weight: 1613.974
- Catalog: Research Areas Cardiovascular Disease
- Create Date: 2018-02-21 02:16:32
- Modify Date: 2024-01-04 11:13:17
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A 71915 is a highly potent and competitive natriuretic peptide receptor A (ANP, NPRA) antagonist (pKi= 9.18). A 71915 displaces [125I]ANP dose dependently, with a Ki of 0.65 nM. A71915( pA2= 9.48) against rat ANP-induced cGMP production in NB-OK-1 cells[1].
| Name | A 71915 |
|---|---|
| Synonyms | (Arg6,β-cyclohexyl-Ala8,D-Tic16,Arg17,Cys18)-Atrial Natriuretic Factor (6-18) amide (mouse, rabbit, rat) |
| Description | A 71915 is a highly potent and competitive natriuretic peptide receptor A (ANP, NPRA) antagonist (pKi= 9.18). A 71915 displaces [125I]ANP dose dependently, with a Ki of 0.65 nM. A71915( pA2= 9.48) against rat ANP-induced cGMP production in NB-OK-1 cells[1]. |
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| Related Catalog | |
| Target |
A 71915 is a highly potent and competitive natriuretic peptide receptor A (ANP, NPRA) antagonist, with a pKi of 9.18. |
| In Vitro | A 71915 combines to Neuroblastoma NB-OK-1 cells, is used in the Cyclic GMP assay. A 71915 shifts the ANP dose-response curve of cyclic GMP production to the right[1]. |
| In Vivo | A 71915 (5 μl; i.m.; 25-30 g male CD-1 mice) affects BNP (1 nmol)- and GRP (0.1 nmol)-induced scratching[2]. A 71915 (30 μg/ kg/ day) inhibits NS-398 on blood pressure decreased[3]. Animal Model: Rat (Male Sprague-Dawley); weighing 150-180 g[3] Dosage: 30 μg/kg/day; infused for 3 weeks Administration: via a mini-osmotic pump Result: The inhibitory effect of NS-398 on blood pressure was attenuated by the pretreatment with A 71915 (30 μg/kg/day). |
| References |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Molecular Formula | C69H116N26O15S2 |
| Molecular Weight | 1613.974 |
| Exact Mass | 1612.855 |
| LogP | -5.73 |
| Index of Refraction | 1.698 |