1962928-21-7

1962928-21-7 structure

Name: PF CBP1
Chemical Name: PF-CBP1 hydrochloride
CAS Number: 1962928-21-7
Molecular Formula: C₂₉H₃₆N₄O₃
Molecular Weight: 488.621
Catalog: Signaling Pathways Epigenetics Epigenetic Reader Domain
Create Date: 2018-03-29 23:46:19
Modify Date: 2025-08-25 12:04:58
PF-CBP1 is a highly selective inhibitor of the CREB binding protein bromodomain[1].

Name	PF-CBP1 hydrochloride
Synonyms	5-(3,5-Dimethyl-1,2-oxazol-4-yl)-1-[2-(4-morpholinyl)ethyl]-2-[2-(4-propoxyphenyl)ethyl]-1H-benzimidazole 1H-Benzimidazole, 5-(3,5-dimethyl-4-isoxazolyl)-1-[2-(4-morpholinyl)ethyl]-2-[2-(4-propoxyphenyl)ethyl]-

Description	PF-CBP1 is a highly selective inhibitor of the CREB binding protein bromodomain[1].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> Epigenetics >> Epigenetic Reader Domain
In Vitro	PF-CBP1 modulates key inflammatory genes in primary macrophages. PF-CBP1 downregulates RGS4 in neurons, a target linked to Parkinson's disease. PF-CBP1 is 139-fold selective over BRD4 in the biochemical assays and >105-fold selective by ITC. F-CBP1 is also a potent inhibitor of EP300 (a result observed for other CBP inhibitors[1].
References	[1]. Chekler EL, et al. Transcriptional Profiling of a Selective CREB Binding Protein Bromodomain Inhibitor Highlights Therapeutic Opportunities. Chem Biol. 2015 Dec 17;22(12):1588-96.