1616392-22-3
1616392-22-3 structure
- Name: Pemrametostat (GSK3326595)
- Chemical Name: GSK3326595
- CAS Number: 1616392-22-3
- Molecular Formula: C24H32N6O3
- Molecular Weight: 452.549
- Catalog: Signaling Pathways Epigenetics Histone Methyltransferase
- Create Date: 2018-06-18 10:46:21
- Modify Date: 2024-01-18 18:36:15
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GSK3326595 is a potent, selective, reversible inhibitor of protein arginine methyltransferase 5 (PRMT5) with an IC50 of 6.2 nM.
| Name | GSK3326595 |
|---|---|
| Synonyms |
6-[(1-Acetyl-4-piperidinyl)amino]-N-[(2S)-3-(3,4-dihydro-2(1H)-isoquinolinyl)-2-hydroxypropyl]-4-pyrimidinecarboxamide
4-Pyrimidinecarboxamide, 6-[(1-acetyl-4-piperidinyl)amino]-N-[(2S)-3-(3,4-dihydro-2(1H)-isoquinolinyl)-2-hydroxypropyl]- EPZ-015938 |
| Description | GSK3326595 is a potent, selective, reversible inhibitor of protein arginine methyltransferase 5 (PRMT5) with an IC50 of 6.2 nM. |
|---|---|
| Related Catalog | |
| Target |
IC50: 6.2 nM (PRMT5)[1] |
| In Vitro | GSK3326595 (EPZ015938), has entered clinical trials for the treatment of solid tumors and non-Hodgkin’s lymphoma[1]. |
| References |
[1]. WO 2016022605 A1 |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 760.3±60.0 °C at 760 mmHg |
| Molecular Formula | C24H32N6O3 |
| Molecular Weight | 452.549 |
| Flash Point | 413.6±32.9 °C |
| Exact Mass | 452.253601 |
| LogP | 2.88 |
| Vapour Pressure | 0.0±2.7 mmHg at 25°C |
| Index of Refraction | 1.626 |
| Storage condition | -20℃ |