1876467-74-1
1876467-74-1 structure
- Name: Elimusertib (BAY-1895344) hydrochloride
- Chemical Name: BAY-1895344
- CAS Number: 1876467-74-1
- Molecular Formula: C20H22ClN7O
- Molecular Weight: 411.89
- Catalog: Signaling Pathways Cell Cycle/DNA Damage ATM/ATR
- Create Date: 2018-05-20 08:00:00
- Modify Date: 2025-09-08 11:06:54
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BAY-1895344 is a potent, orally available and selective ATR inhibitor, with IC50 of 7 nM. Anti-tumor activity[1].
| Name | BAY-1895344 |
|---|---|
| Synonyms | MFCD31561442 |
| Description | BAY-1895344 is a potent, orally available and selective ATR inhibitor, with IC50 of 7 nM. Anti-tumor activity[1]. |
|---|---|
| Related Catalog | |
| Target |
ATR:7 nM (IC50) |
| In Vitro | BAY-1895344 potently inhibits the proliferation of a broad spectrum of human tumor cell lines with a median IC50 of 78 nM[1]. BAY-1895344 potently suppresses hydroxyurea-induced H2AX phosphorylation (IC50, 36 nM)[1]. |
| In Vivo | BAY-1895344 shows potent anti-tumor efficacy in monotherapy in a variety of xenograft models of ovarian and colorectal cancer, and causes complete tumor remission in mantle cell lymphoma models[2]. |
| References |
| Molecular Formula | C20H22ClN7O |
|---|---|
| Molecular Weight | 411.89 |
| Storage condition | -20℃ |
| Hazard Codes | N |
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