2098902-68-0

2098902-68-0 structure

Name: KDM4D-IN-1
Chemical Name: KDM4D-IN-1
CAS Number: 2098902-68-0
Molecular Formula: C₁₁H₇N₅O
Molecular Weight: 225.21
Catalog: Signaling Pathways Epigenetics Histone Demethylase
Create Date: 2018-05-25 08:00:00
Modify Date: 2024-01-08 15:27:44
KDM4D-IN-1 is a new histone lysine demethylase 4D (KDM4D) inhibitor with an IC50 value of 0.41±0.03 μM.

Name	KDM4D-IN-1

Description	KDM4D-IN-1 is a new histone lysine demethylase 4D (KDM4D) inhibitor with an IC50 value of 0.41±0.03 μM.
Related Catalog	Signaling Pathways >> Epigenetics >> Histone Demethylase Research Areas >> Cancer
Target	IC50:0.41±0.03 μM (KDM4D)[1]
In Vitro	KDM4D-IN-1 (Compound 10r) is the most potent one with an IC50 value of 0.41±0.03 μM against KDM4D. KDM4D-IN-1 displays almost no activity against KDM2B, KDM3B, and KDM5A (IC50>10 μM), indicating that KDM4D-IN-1 has a good selectivity for KDM4D against other selected KDMs[1].
References	[1]. Fang Z, et al. Discovery of pyrazolo[1,5-a]pyrimidine-3-carbonitrile derivatives as a new class of histone lysine demethylase 4D (KDM4D) inhibitors. Bioorg Med Chem Lett. 2017 Jul 15;27(14):3201-3204.