1263094-00-3

1263094-00-3 structure

Name: 7-Chlorokynurenic acid sodium salt
Chemical Name: 7-Chlorokynurenic acid sodium salt
CAS Number: 1263094-00-3
Molecular Formula: C₁₀H₅ClNNaO₃
Molecular Weight: 245.594
Catalog: Signaling Pathways Membrane Transporter/Ion Channel iGluR
Create Date: 2018-05-03 09:32:04
Modify Date: 2024-01-09 18:31:27
7-Chlorokynurenic acid sodium salt is a selective antagonist at the glycine modulatory site of the N-methyl-D-aspartate receptor complex and also a potent inhibitor of the reuptake of glutamate into synaptic vesicles with a Ki of 0.59 μM.

Name	7-Chlorokynurenic acid sodium salt
Synonyms	Sodium 7-chloro-4-hydroxy-2-quinolinecarboxylate 2-Quinolinecarboxylic acid, 7-chloro-4-hydroxy-, sodium salt (1:1) Sodium 7-chloro-4-hydroxyquinoline-2-carboxylate

Description	7-Chlorokynurenic acid sodium salt is a selective antagonist at the glycine modulatory site of the N-methyl-D-aspartate receptor complex and also a potent inhibitor of the reuptake of glutamate into synaptic vesicles with a Ki of 0.59 μM.
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR Signaling Pathways >> Neuronal Signaling >> iGluR Research Areas >> Neurological Disease
Target	N-methyl-D-aspartate receptor[1] Ki: 0.59 μM (reuptake of glutamate)[1]
References	[1]. Kemp JA, et al. 7-Chlorokynurenic acid is a selective antagonist at the glycine modulatory site of the N-methyl-D-aspartate receptor complex. Proc Natl Acad Sci U S A. 1988 Sep;85(17):6547-50. [2]. Bartlett RD, et al. Substituted quinolines as inhibitors of L-glutamate transport into synaptic vesicles. Neuropharmacology. 1998 Jul;37(7):839-46.