1334302-63-4

1334302-63-4 structure

Name: Itacitinib adipate
Chemical Name: Itacitinib adipate
CAS Number: 1334302-63-4
Molecular Formula: C₃₂H₃₃F₄N₉O₅
Molecular Weight: 699.655
Catalog: Research Areas Cancer
Create Date: 2018-06-04 09:23:54
Modify Date: 2024-01-05 18:06:02
Itacitinib adipate is a selective JAK1 inhibitor which has been tested for efficacy and safety in a phase II trial in myelofibrosis.

Name	Itacitinib adipate
Synonyms	Itacitinib adipate Hexanedioic acid - (1-{1-[3-fluoro-2-(trifluoromethyl)isonicotinoyl]-4-piperidinyl}-3-[4-(1H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]-3-azetidinyl)acetonitrile (1:1) UNII-XZG407XE0Y INCB039110 adipate (1-{1-[3-fluoro-2-(trifluoromethyl)pyridine-4-carbonyl]piperidin-4-yl}-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]azetidin-3-yl)acetonitrile monohexanedioate Hexanedioic acid, compd. with 1-[1-[[3-fluoro-2-(trifluoromethyl)-4-pyridinyl]carbonyl]-4-piperidinyl]-3-[4-(1H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]-3-azetidineacetonitrile (1:1)

Description	Itacitinib adipate is a selective JAK1 inhibitor which has been tested for efficacy and safety in a phase II trial in myelofibrosis.
Related Catalog	Research Areas >> Cancer
Target	JAK1
References	[1]. Griesshammer M, et al. The BCR-ABL1-negative myeloproliferative neoplasms: a review of JAK inhibitors in the therapeutic armamentarium. Expert Opin Pharmacother. 2017 Dec;18(18):1929-1938.