1423186-80-4
1423186-80-4 structure
- Name: RIP2 kinase inhibitor 1
- Chemical Name: RIP2 kinase inhibitor 1
- CAS Number: 1423186-80-4
- Molecular Formula: C21H22N4O4S2
- Molecular Weight: 458.554
- Catalog: Signaling Pathways Apoptosis RIP kinase
- Create Date: 2018-03-29 08:46:52
- Modify Date: 2024-01-14 22:08:18
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RIP2 kinase inhibitor 1 is a receptor interacting protein-2 (RIP2) kinase inhibitor extracted from patent WO/2014043446 A1, compound example 1.
| Name | RIP2 kinase inhibitor 1 |
|---|---|
| Synonyms |
2-({4-(1,3-Benzothiazol-5-ylamino)-6-[(2-methyl-2-propanyl)sulfonyl]-7-quinazolinyl}oxy)ethanol
Ethanol, 2-[[4-(5-benzothiazolylamino)-6-[(1,1-dimethylethyl)sulfonyl]-7-quinazolinyl]oxy]- |
| Description | RIP2 kinase inhibitor 1 is a receptor interacting protein-2 (RIP2) kinase inhibitor extracted from patent WO/2014043446 A1, compound example 1. |
|---|---|
| Related Catalog | |
| Target |
RIP2 Kinase[1] |
| In Vitro | RIP2 kinase inhibitor 1 is a novel prodrug of a quinazolyl amine that inhibits RIP2 kinase. Receptor interacting protein-2 (RIP2) kinase, which is also referred to as CARD3, RICK, CARDIAK, or RIPK2, is a TKL family serine/threonine protein kinase involved in innate immune signaling. RIP2 kinase is composed of an N-terminal kinase domain and a C-terminal caspase-recruitment domain (CARD) linked via an intermediate (IM) region. The CARD domain of RIP2 kinase mediates interaction with other CARD-containing proteins, such as NODI and NOD2. NODI and NOD2 are cytoplasmic receptors which play a key role in innate immune surveillance. They recognize both gram positive and gram negative bacterial pathogens and are activated by specific peptidoglycan motifs, diaminopimelic acid (i.e., DAP) and muramyl dipeptide[1]. |
| Animal Admin | Rats[1] Rats are orally pre-dosed with RIP2 kinase inhibitor 1, at a dose of 2 mg/kg (8 rats) and with Prednisolone (8 rats, used as a positive control), followed by dosing with L18-MDP (50 μg/rat) 0.25 h/min after pre-dosing. Combined cytokine levels (IL8, TNFa, IL6 and IL-Ιβ) in whole blood samples taken from the rats in this study are measured using an antibody based detection. The combined cytokine response is calculated as the averaged response for the 4 cytokines measured relative to the response observed in the vehicle-treated mice, and are depicted as the mean±standard error of the mean (n=8 rats/group). |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 719.9±60.0 °C at 760 mmHg |
| Molecular Formula | C21H22N4O4S2 |
| Molecular Weight | 458.554 |
| Flash Point | 389.2±32.9 °C |
| Exact Mass | 458.108246 |
| LogP | 1.38 |
| Vapour Pressure | 0.0±2.4 mmHg at 25°C |
| Index of Refraction | 1.679 |
| Storage condition | 2-8℃ |