1429624-84-9

1429624-84-9 structure

Name: PI4KIIIbeta-IN-9
Chemical Name: PI4KIIIbeta-IN-9
CAS Number: 1429624-84-9
Molecular Formula: C₂₃H₂₅N₃O₅S₂
Molecular Weight: 487.592
Catalog: Signaling Pathways PI3K/Akt/mTOR PI4K
Create Date: 2018-05-08 15:18:25
Modify Date: 2024-01-12 17:22:20
PI4KIIIbeta-IN-9 is a potent PI4KIIIβ inhibitor with an IC50 of 7 nM. PI4KIIIbeta-IN-9 also inhibits PI3Kδ and PI3Kγ with IC50s of 152 nM and 1046 nM, respectively.

Name	PI4KIIIbeta-IN-9
Synonyms	Cyclopentanecarboxamide, N-[5-[3-[[(4-hydroxyphenyl)amino]sulfonyl]-4-methoxyphenyl]-4-methyl-2-thiazolyl]- N-(5-{3-[(4-Hydroxyphenyl)sulfamoyl]-4-methoxyphenyl}-4-methyl-1,3-thiazol-2-yl)cyclopentanecarboxamide

Description	PI4KIIIbeta-IN-9 is a potent PI4KIIIβ inhibitor with an IC50 of 7 nM. PI4KIIIbeta-IN-9 also inhibits PI3Kδ and PI3Kγ with IC50s of 152 nM and 1046 nM, respectively.
Related Catalog	Signaling Pathways >> PI3K/Akt/mTOR >> PI4K Research Areas >> Cancer
Target	PI4KIIIβ:7 nM (IC50) PI4KIIIα:2.6 μM (IC50) PI3Kδ:152 nM (IC50) PI3Kγ:1046 nM (IC50) PI3Kα:2 μM (IC50) PI3KC2γ:1 μM (IC50)
In Vitro	PI4KIIIbeta-IN-9 (Compound 9) shows weak inhibition of PI3KC2γ (IC50 ~1 µM), PI3Kα (~2 µM), and PI4KIIIα (~2.6 µM) and <50% inhibition at concentrations up to 20 µM for PI4K2α, PI4K2β, and PI3Kβ. PI4KIIIbeta-IN-9 (Compound 9) forms a crescent shape that conforms to the active site of PI4KIIIβ. This molecule makes extensive contacts with PI4KIIIβ[1].
References	[1]. Rutaganira FU, et al. Design and Structural Characterization of Potent and Selective Inhibitors of Phosphatidylinositol 4 Kinase IIIβ. J Med Chem. 2016 Mar 10;59(5):1830-9.