PI4KIIIbeta-IN-9
Modify Date: 2024-01-12 17:22:20
PI4KIIIbeta-IN-9 structure
|
Common Name | PI4KIIIbeta-IN-9 | ||
|---|---|---|---|---|
| CAS Number | 1429624-84-9 | Molecular Weight | 487.592 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C23H25N3O5S2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of PI4KIIIbeta-IN-9PI4KIIIbeta-IN-9 is a potent PI4KIIIβ inhibitor with an IC50 of 7 nM. PI4KIIIbeta-IN-9 also inhibits PI3Kδ and PI3Kγ with IC50s of 152 nM and 1046 nM, respectively. |
| Name | PI4KIIIbeta-IN-9 |
|---|---|
| Synonym | More Synonyms |
| Description | PI4KIIIbeta-IN-9 is a potent PI4KIIIβ inhibitor with an IC50 of 7 nM. PI4KIIIbeta-IN-9 also inhibits PI3Kδ and PI3Kγ with IC50s of 152 nM and 1046 nM, respectively. |
|---|---|
| Related Catalog | |
| Target |
PI4KIIIβ:7 nM (IC50) PI4KIIIα:2.6 μM (IC50) PI3Kδ:152 nM (IC50) PI3Kγ:1046 nM (IC50) PI3Kα:2 μM (IC50) PI3KC2γ:1 μM (IC50) |
| In Vitro | PI4KIIIbeta-IN-9 (Compound 9) shows weak inhibition of PI3KC2γ (IC50 ~1 µM), PI3Kα (~2 µM), and PI4KIIIα (~2.6 µM) and <50% inhibition at concentrations up to 20 µM for PI4K2α, PI4K2β, and PI3Kβ. PI4KIIIbeta-IN-9 (Compound 9) forms a crescent shape that conforms to the active site of PI4KIIIβ. This molecule makes extensive contacts with PI4KIIIβ[1]. |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Molecular Formula | C23H25N3O5S2 |
| Molecular Weight | 487.592 |
| Exact Mass | 487.123566 |
| LogP | 3.91 |
| Index of Refraction | 1.659 |
| Storage condition | 2-8℃ |
| Cyclopentanecarboxamide, N-[5-[3-[[(4-hydroxyphenyl)amino]sulfonyl]-4-methoxyphenyl]-4-methyl-2-thiazolyl]- |
| N-(5-{3-[(4-Hydroxyphenyl)sulfamoyl]-4-methoxyphenyl}-4-methyl-1,3-thiazol-2-yl)cyclopentanecarboxamide |