1448693-69-3

1448693-69-3 structure

Name: GCN2-IN-1
Chemical Name: GCN2-IN-1
CAS Number: 1448693-69-3
Molecular Formula: C₁₉H₁₈N₁₀O
Molecular Weight: 402.413
Catalog: Signaling Pathways Metabolic Enzyme/Protease Ser/Thr Protease
Create Date: 2018-03-21 21:20:49
Modify Date: 2024-02-02 21:54:35
GCN2-IN-1 is a potent general control nonderepressible 2 kinase (GCN2) inhibitor with IC50s of <0.3 μM in the enzyme and cell assay.

Name	GCN2-IN-1
Synonyms	MFCD30345302 3-(1H-Indazol-6-yl)-N-[1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl]-3H-[1,2,3]triazolo[4,5-d]pyrimidin-5-amine 3H-1,2,3-Triazolo[4,5-d]pyrimidin-5-amine, 3-(1H-indazol-6-yl)-N-[1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl]-

Description	GCN2-IN-1 is a potent general control nonderepressible 2 kinase (GCN2) inhibitor with IC50s of <0.3 μM in the enzyme and cell assay.
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Ser/Thr Protease Research Areas >> Cancer
Target	IC50: <0.3 μM (GCN2)[1]
In Vitro	GCN2-IN-1 (Compound A-92) is a GCN2 inhibitor, which may be useful as a chemotherapeutic drug for the treatment of cancer[1].
References	[1]. Brazeau JF, et al. Triazolo[4,5-d]pyrimidine Derivatives as Inhibitors of GCN2. ACS Med Chem Lett. 2014 Feb 12;5(4):282-3.