1628428-01-2

1628428-01-2 structure

Name: PKR-IN-2
Chemical Name: PKR-IN-2
CAS Number: 1628428-01-2
Molecular Formula: C₂₄H₂₈N₄O₄S
Molecular Weight: 468.569
Catalog: Research Areas Cancer
Create Date: 2018-05-18 18:40:28
Modify Date: 2024-01-06 18:13:25
PKR-IN-2 is a pyruvate kinase (PKR) activator, extracted from patent WO2014139144A1, compound 160, has an IC50 of ＜100 nM for. PKR (R510Q), PKR (R532W), PKR (WT), and PKR (WT Cell Based).IC50 value: ＜100 nM (AC50)Target: PKR

Name	PKR-IN-2
Synonyms	5-Quinoxalinesulfonamide, N-[4-[[4-hydroxy-4-(2-methylpropyl)-1-piperidinyl]carbonyl]phenyl]- WLI3QP8XYK N-{4-[(4-Hydroxy-4-isobutyl-1-piperidinyl)carbonyl]phenyl}-5-quinoxalinesulfonamide

Description	PKR-IN-2 is a pyruvate kinase (PKR) activator, extracted from patent WO2014139144A1, compound 160, has an IC50 of ＜100 nM for. PKR (R510Q), PKR (R532W), PKR (WT), and PKR (WT Cell Based).IC50 value: ＜100 nM (AC50)Target: PKR
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Cancer
References	[1]. Popovici-Muller, et al. Preparation of N-(piperidinecarbonylphenyl) sulfonamide compounds as pyruvate kinase modulators. From PCT Int. Appl. (2014), WO2014139144A1 20140918. [2]. Cianchetta Giovanni, et al. Preparation of aroylpiperidines, particularly arysulfonylamino and heteroarylsulfonylamino substituted, as pyruvate kinase PKM2 modulators useful in the treatment of cancer and compositions containing them. From PCT Int. Appl.