PKR-IN-2

Modify Date: 2024-01-06 18:13:25

PKR-IN-2 structure	Common Name	PKR-IN-2
	CAS Number	1628428-01-2	Molecular Weight	468.569
	Density	1.3±0.1 g/cm3	Boiling Point	681.5±65.0 °C at 760 mmHg
	Molecular Formula	C₂₄H₂₈N₄O₄S	Melting Point	N/A
	MSDS	N/A	Flash Point	365.9±34.3 °C

Use of PKR-IN-2

PKR-IN-2 is a pyruvate kinase (PKR) activator, extracted from patent WO2014139144A1, compound 160, has an IC50 of ＜100 nM for. PKR (R510Q), PKR (R532W), PKR (WT), and PKR (WT Cell Based).IC50 value: ＜100 nM (AC50)Target: PKR

Name	PKR-IN-2
Synonym	More Synonyms

Description	PKR-IN-2 is a pyruvate kinase (PKR) activator, extracted from patent WO2014139144A1, compound 160, has an IC50 of ＜100 nM for. PKR (R510Q), PKR (R532W), PKR (WT), and PKR (WT Cell Based).IC50 value: ＜100 nM (AC50)Target: PKR
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Cancer
References	[1]. Popovici-Muller, et al. Preparation of N-(piperidinecarbonylphenyl) sulfonamide compounds as pyruvate kinase modulators. From PCT Int. Appl. (2014), WO2014139144A1 20140918. [2]. Cianchetta Giovanni, et al. Preparation of aroylpiperidines, particularly arysulfonylamino and heteroarylsulfonylamino substituted, as pyruvate kinase PKM2 modulators useful in the treatment of cancer and compositions containing them. From PCT Int. Appl.

Description

Related Catalog

Signaling Pathways >> Others >> Others

Research Areas >> Cancer

References

[1]. Popovici-Muller, et al. Preparation of N-(piperidinecarbonylphenyl) sulfonamide compounds as pyruvate kinase modulators. From PCT Int. Appl. (2014), WO2014139144A1 20140918.

[2]. Cianchetta Giovanni, et al. Preparation of aroylpiperidines, particularly arysulfonylamino and heteroarylsulfonylamino substituted, as pyruvate kinase PKM2 modulators useful in the treatment of cancer and compositions containing them. From PCT Int. Appl.

Density	1.3±0.1 g/cm3
Boiling Point	681.5±65.0 °C at 760 mmHg
Molecular Formula	C₂₄H₂₈N₄O₄S
Molecular Weight	468.569
Flash Point	365.9±34.3 °C
Exact Mass	468.183136
LogP	1.12
Vapour Pressure	0.0±2.2 mmHg at 25°C
Index of Refraction	1.644
Storage condition	2-8℃

5-Quinoxalinesulfonamide, N-[4-[[4-hydroxy-4-(2-methylpropyl)-1-piperidinyl]carbonyl]phenyl]-

WLI3QP8XYK

N-{4-[(4-Hydroxy-4-isobutyl-1-piperidinyl)carbonyl]phenyl}-5-quinoxalinesulfonamide

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: PKR-IN-2
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Purity: 99.0%
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Price: $462/10mM*1mLinDMSO

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PKR-IN-2

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