177904-00-6

177904-00-6 structure

Name: PD-159020
Chemical Name: PD-159020
CAS Number: 177904-00-6
Molecular Formula: C₃₂H₂₅NO₈
Molecular Weight: 551.543
Catalog: Signaling Pathways GPCR/G Protein Endothelin Receptor
Create Date: 2018-06-18 04:00:05
Modify Date: 2025-09-18 17:59:15
PD-159020 is a non-selective ETA/ETB antagonist, with IC50s of 30 and 50 nM for hETA and hETB, respectively.

Name	PD-159020
Synonyms	1H-Indole-2-carboxylic acid, 3-(1,3-benzodioxol-5-yl)-1-(1,3-benzodioxol-5-ylmethyl)-5-methoxy-6-(phenylmethoxy)- 3-(1,3-Benzodioxol-5-yl)-1-(1,3-benzodioxol-5-ylmethyl)-6-(benzyloxy)-5-methoxy-1H-indole-2-carboxylic acid

Description	PD-159020 is a non-selective ETA/ETB antagonist, with IC50s of 30 and 50 nM for hETA and hETB, respectively.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Endothelin Receptor Research Areas >> Cardiovascular Disease
Target	IC50: 30 nM (hETA), 50 nM (hETB)[1]
In Vitro	PD-159020 demonstrates excellent inhibition of arachidonic acid release, AAR-B, with an IC50 of 0.23 μM.
References	[1]. Amy Mbunker, et al. 1,3-diaryl-2-carboxyindoles as potent non-peptide endothelin antagonists. Bioorganic & Medicinal Chemistry Letters. Volume 6, Issue 9, 7 May 1996, Pages 1061-1066