Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: manitimus
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Purity: 98.0%
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202057-76-9

202057-76-9 structure

202057-76-9 structure

Name: Manitimus
Chemical Name: Manitimus
CAS Number: 202057-76-9
Molecular Formula: C₁₅H₁₁F₃N₂O₂
Molecular Weight: 308.255
Catalog: Research Areas Inflammation/Immunology
Create Date: 2018-04-02 06:17:26
Modify Date: 2024-02-04 21:21:20
Manitimus is an inhibitor of dehydroorotate dehydrogenase, and a potent immunosuppressive drug.

Name	Manitimus
Synonyms	2-Hepten-6-ynamide, 2-cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-, (2Z)- (2Z)-2-Cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2-hepten-6-ynamide Manitimus 2-cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)-2-hepten-6-ynamide

Description	Manitimus is an inhibitor of dehydroorotate dehydrogenase, and a potent immunosuppressive drug.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
In Vivo	In the Manitimus-treated rats, there is a dose-related, differential effect: mean survival is 15.7 days in group 4 (Manitimus 5 mg/kg), 19.1 days in group 5 (Manitimus 10 mg/kg) and 25.4 days in group 6 (Manitimus 20 mg/kg)[1]. Manitimus (15 mg/kg, p.o.) results in a significant decrease in neointimal area and percentage of stenosis versus the control rats, and diminishes the effect that CMV infection results in a significant increase in intimal and medial cross-sectional area and medial wall thickness of the vein grafts[2].
Animal Admin	The whole experiment consists of a total of four experimental groups (n = 10 animals/group) which all undergo surgery. Furthermore, rats are either infected with CMV, treated with Manitimusor both. A control group only receive the Manitimus solvent (1 mL of a 1% carboxymethylcellulose solution in water). Infection is established by inoculating rats intraperitoneally with 1.25×106 plaque-forming units of homogenized salivary gland-derived rat CMV immediately after surgery.
References	[1]. Birnbaum F, et al. The new malononitrilamide immunosuppressant FK778 prolongs corneal allograft survival in the rat keratoplasty model. Eye (Lond). 2007 Dec;21(12):1516-23. Epub 2007 Mar 30. [2]. Kloppenburg G, et al. FK778 attenuates cytomegalovirus-enhanced vein graft intimal hyperplasia in a rat model. Intervirology. 2009;52(4):189-95.

Density	1.4±0.1 g/cm3
Boiling Point	489.4±45.0 °C at 760 mmHg
Molecular Formula	C₁₅H₁₁F₃N₂O₂
Molecular Weight	308.255
Flash Point	249.8±28.7 °C
Exact Mass	308.077271
LogP	3.49
Vapour Pressure	0.0±1.3 mmHg at 25°C
Index of Refraction	1.562
Storage condition	2-8℃