3374-88-7

3374-88-7 structure

Name: ICA
Chemical Name: ICA
CAS Number: 3374-88-7
Molecular Formula: C₁₃H₁₀N₄S
Molecular Weight: 254.310
Catalog: Signaling Pathways Anti-infection Parasite
Create Date: 2018-05-06 15:48:55
Modify Date: 2024-01-06 11:31:37
ICA (N-(pyridin-2-yl)-4-(pyridin-2-yl)thiazol-2-amine) is a SK channel inhibitor that has antileishmanial activity with an IC50 of 2.1 µM.

Name	ICA
Synonyms	N-[4-(2-Pyridinyl)-1,3-thiazol-2-yl]-2-pyridinamine Pyridin-2-yl-(4-pyridin-2-yl-thiazol-2-yl)-amine TCMDC-124275 N-[4-(Pyridin-2-yl)-1,3-thiazol-2-yl]pyridin-2-amine 2-Pyridinamine, N-[4-(2-pyridinyl)-2-thiazolyl]-

Description	ICA (N-(pyridin-2-yl)-4-(pyridin-2-yl)thiazol-2-amine) is a SK channel inhibitor that has antileishmanial activity with an IC50 of 2.1 µM.
Related Catalog	Signaling Pathways >> Anti-infection >> Parasite Research Areas >> Cardiovascular Disease Research Areas >> Infection
Target	IC50: 2.1 µM (Antileishmanial)[1]
In Vitro	The SK channel inhibitor ICA exhibits antiarrhythmic effects. ICA prevents electrically induced runs of atrial fibrillation in the isolated right atrium and induces atrial postrepolarization refractoriness and depolarizes resting membrane potential. ICA at 1 to 10 μM slows conduction velocity. At increased pacing frequencies, SK channel inhibition by ICA (10-30 μM) demonstrates prominent depression of other sodium channel-dependent parameters[2].
References	[1]. Bhuniya D, et al. Aminothiazoles: Hit to lead development to identify antileishmanial agents. Eur J Med Chem. 2015 Sep 18;102:582-93. [2]. Skibsbye L, et al. Antiarrhythmic Mechanisms of SK Channel Inhibition in the Rat Atrium. J Cardiovasc Pharmacol. 2015 Aug;66(2):165-76.