ICA

Modify Date: 2024-01-06 11:31:37

ICA structure	Common Name	ICA
	CAS Number	3374-88-7	Molecular Weight	254.310
	Density	1.3±0.1 g/cm3	Boiling Point	466.4±48.0 °C at 760 mmHg
	Molecular Formula	C₁₃H₁₀N₄S	Melting Point	N/A
	MSDS	N/A	Flash Point	235.9±29.6 °C

Use of ICA

ICA (N-(pyridin-2-yl)-4-(pyridin-2-yl)thiazol-2-amine) is a SK channel inhibitor that has antileishmanial activity with an IC50 of 2.1 µM.

Name	ICA
Synonym	More Synonyms

Description	ICA (N-(pyridin-2-yl)-4-(pyridin-2-yl)thiazol-2-amine) is a SK channel inhibitor that has antileishmanial activity with an IC50 of 2.1 µM.
Related Catalog	Signaling Pathways >> Anti-infection >> Parasite Research Areas >> Cardiovascular Disease Research Areas >> Infection
Target	IC50: 2.1 µM (Antileishmanial)[1]
In Vitro	The SK channel inhibitor ICA exhibits antiarrhythmic effects. ICA prevents electrically induced runs of atrial fibrillation in the isolated right atrium and induces atrial postrepolarization refractoriness and depolarizes resting membrane potential. ICA at 1 to 10 μM slows conduction velocity. At increased pacing frequencies, SK channel inhibition by ICA (10-30 μM) demonstrates prominent depression of other sodium channel-dependent parameters[2].
References	[1]. Bhuniya D, et al. Aminothiazoles: Hit to lead development to identify antileishmanial agents. Eur J Med Chem. 2015 Sep 18;102:582-93. [2]. Skibsbye L, et al. Antiarrhythmic Mechanisms of SK Channel Inhibition in the Rat Atrium. J Cardiovasc Pharmacol. 2015 Aug;66(2):165-76.

Density	1.3±0.1 g/cm3
Boiling Point	466.4±48.0 °C at 760 mmHg
Molecular Formula	C₁₃H₁₀N₄S
Molecular Weight	254.310
Flash Point	235.9±29.6 °C
Exact Mass	254.062622
LogP	1.39
Vapour Pressure	0.0±1.2 mmHg at 25°C
Index of Refraction	1.694
Storage condition	2-8℃

N-[4-(2-Pyridinyl)-1,3-thiazol-2-yl]-2-pyridinamine

Pyridin-2-yl-(4-pyridin-2-yl-thiazol-2-yl)-amine

TCMDC-124275

N-[4-(Pyridin-2-yl)-1,3-thiazol-2-yl]pyridin-2-amine

2-Pyridinamine, N-[4-(2-pyridinyl)-2-thiazolyl]-

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: ICA
Price: Negotiable
Purity: 99.0%
Delivery: 10 Day
Contact: Huang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: GW354586X
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

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Price: $504/10mM*1mLinDMSO

Reference only. check more ICA price