439153-64-7
439153-64-7 structure
- Name: LNK754
- Chemical Name: LNK754
- CAS Number: 439153-64-7
- Molecular Formula: C29H22ClN3O2
- Molecular Weight: 479.96
- Catalog: Signaling Pathways Metabolic Enzyme/Protease Farnesyl Transferase
- Create Date: 2018-01-29 23:47:20
- Modify Date: 2024-01-02 13:01:52
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LNK754 is a farnesyltransferase inhibitor, used for the treatment of cancer and Alzheimer's disease.
| Name | LNK754 |
|---|---|
| Synonyms |
(2R,3R)-2,3-Dihydroxysuccinic acid - 6-[(4-chlorophenyl)(hydroxy)(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-ethynylphenyl)-1-methyl-2(1H)-quinolinone (1:1)
Butanedioic acid, 2,3-dihydroxy-, (2R,3R)-, compd. with 6-[(4-chlorophenyl)hydroxy(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-ethynylphenyl)-1-methyl-2(1H)-quinolinone (1:1) |
| Description | LNK754 is a farnesyltransferase inhibitor, used for the treatment of cancer and Alzheimer's disease. |
|---|---|
| Related Catalog | |
| In Vivo | LNK-754 (0.9 mg/kg) significantly reduces α-synuclein plaques in a mouse model of PD, APP(SL), at 6 months of age for 3 months[1]. |
| References |
[1]. Keith T Gagnon. HD Therapeutics-CHDI Fifth Annual Conference. IDrugs. 2010 Apr;13(4):219-23. |
| Molecular Formula | C29H22ClN3O2 |
|---|---|
| Molecular Weight | 479.96 |
| Storage condition | 2-8℃ |