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101462-82-2

101462-82-2 structure

101462-82-2 structure

Name: β-CGRP (human)
Chemical Name: β-CGRP, human
CAS Number: 101462-82-2
Molecular Formula: C₁₆₂H₂₆₉N₅₁O₄₈S₃
Molecular Weight: 3795.4
Catalog: Peptides
Create Date: 2018-03-21 16:41:28
Modify Date: 2026-07-01 12:08:54
β-CGRP, human is one of calcitonin peptides, acts via the complex of calcitonin-receptor-like receptor (CRLR) and receptor-activity-modifying protein (RAMP), with IC50s of 1 nM and 300 nM for CRLR/RAMP1 and CRLR/RAMP2 in cells.

Name	β-CGRP, human
Synonyms	b-CP (huMan) CP-II (HUMAN) β-CP, human、Calcitonin Gene Related Ptide II, human, CP-II CP HUMAN Β-CP, HUMAN ACETATE β-CP,human acetate Calcitonin Gene Related Ptide, CP (beta), human BETA-CALCITONIN GENE RELATED PTIDE HUMAN H-ALA-CYS-ASN-THR-ALA-THR-CYS-VAL-THR-HIS-G-LEU-ALA-GLY-LEU-LEU-SER-G-SER-GLY-GLY-MET-VAL-LYS-SER-ASN-PHE-VAL-PRO-THR-ASN-VAL-GLY-SER-LYS-ALA-PHE-NH2 CP-II (Human) (acetate) CP-II β-CP (human),CP-II (human) ACNTATCVTHRLAGLLSRSGGMVKSNFVPTNVGSKAF-NH2 β-CP， human SER-CYS-ASN-THR-ALA-THR-CYS-VAL-THR-HIS-G-LEU-ALA-GLY-LEU-LEU-SER-G-SER-GLY-GLY-VAL-VAL-LYS-ASP-ASN-PHE-VAL-PRO-THR-ASN-VAL-GLY-SER-GLU-ALA-PHE-NH2(CYS&CYS BRIDGE) b-Calcitonin gene-related ptide BETA-CALCITONIN GENE RELATED PTIDE CALCITONIN GENE-RELATED PTIDE-II, HUMAN CALCITONIN GENE RELATED PTIDE HUMAN CALCITONIN GENE RELATED PTIDE Human β-CP Human β-CP acetate βCP, human acetate,β CP, human acetate β-CP (huMan) CP-II (huMan) ALA-CYS-ASN-THR-ALA-THR-CYS-VAL-THR-HIS-G-LEU-ALA-GLY-LEU-LEU-SER-G-SER-GLY-GLY-MET-VAL-LYS-SER-ASN-PHE-VAL-PRO-THR-ASN-VAL-GLY-SER-LYS-ALA-PHE-NH2 BETA-CP, HUMAN Calcitonin Gene Related Ptide II, human, CP-II

Description	β-CGRP, human is one of calcitonin peptides, acts via the complex of calcitonin-receptor-like receptor (CRLR) and receptor-activity-modifying protein (RAMP), with IC50s of 1 nM and 300 nM for CRLR/RAMP1 and CRLR/RAMP2 in cells.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> CGRP Receptor Signaling Pathways >> Neuronal Signaling >> CGRP Receptor Peptides Research Areas >> Cardiovascular Disease Research Areas >> Inflammation/Immunology
Target	IC50: 1 nM (CRLR/RAMP1, cell assay), 300 nM (CRLR/RAMP2, cell assay)[1]
In Vitro	β-CGRP, human is one of calcitonin peptides, acts via complex of calcitonin-receptor-like receptor (CRLR) and receptor-activity-modifying protein (RAMP), with IC50s of 1 nM in both SK-N-MC and Swiss 3T3 cells express CRLR and RAMP1, and 130 nM and 300 nM in NG108-15 and HEK293T cells expressing CRLR and RAMP2[1]. CGRP is a potent vasodilator and also shows pro- and -anti-inflammatory activity[2].
References	[1]. McLatchie LM, et al. RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor. Nature. 1998 May 28;393(6683):333-9. [2]. Russell FA, et al. Calcitonin gene-related peptide: physiology and pathophysiology. Physiol Rev. 2014 Oct;94(4):1099-142.

Molecular Formula	C₁₆₂H₂₆₉N₅₁O₄₈S₃
Molecular Weight	3795.4
Exact Mass	3793.9371779
Storage condition	−20°C

WGK Germany	3

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