139652-01-0
139652-01-0 structure
- Name: Sigma-LIGAND-1
- Chemical Name: Sigma-LIGAND-1
- CAS Number: 139652-01-0
- Molecular Formula: C27H33NO4
- Molecular Weight: 435.56
- Catalog: Signaling Pathways GPCR/G Protein Sigma Receptor
- Create Date: 2018-03-03 03:20:41
- Modify Date: 2024-01-02 12:13:42
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Sigma-LIGAND-1 is a selective sigma receptor ligand, has receptor IC50s of 16 nM at the DTG site, 19 nM at the PPP site, and a Ki of 4000 nM at the dopamine D2 receptor.
| Name | Sigma-LIGAND-1 |
|---|
| Description | Sigma-LIGAND-1 is a selective sigma receptor ligand, has receptor IC50s of 16 nM at the DTG site, 19 nM at the PPP site, and a Ki of 4000 nM at the dopamine D2 receptor. |
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| Related Catalog | |
| Target |
IC50: 16 nM (DTG site of sigma receptor), 19 nM (PPP site of sigma receptor)[1] Ki: 4000 nM (Dopamine D2 receptor)[1] |
| In Vivo | Administration of Sigma-LIGAND-1 would reverse amphetamine-induced hyperlocomotion in mice, a behavioral model sensitive to antipsychotic compounds. Sigma-LIGAND-1 and its structural analogues have the potential antipsychotic activity[1]. |
| References |
| Molecular Formula | C27H33NO4 |
|---|---|
| Molecular Weight | 435.56 |