139652-01-0

139652-01-0 structure

139652-01-0 structure

Name: Sigma-LIGAND-1
Chemical Name: Sigma-LIGAND-1
CAS Number: 139652-01-0
Molecular Formula: C₂₇H₃₃NO₄
Molecular Weight: 435.56
Catalog: Signaling Pathways GPCR/G Protein Sigma Receptor
Create Date: 2018-03-03 03:20:41
Modify Date: 2024-01-02 12:13:42
Sigma-LIGAND-1 is a selective sigma receptor ligand, has receptor IC50s of 16 nM at the DTG site, 19 nM at the PPP site, and a Ki of 4000 nM at the dopamine D2 receptor.

Name	Sigma-LIGAND-1

Description	Sigma-LIGAND-1 is a selective sigma receptor ligand, has receptor IC50s of 16 nM at the DTG site, 19 nM at the PPP site, and a Ki of 4000 nM at the dopamine D2 receptor.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Sigma Receptor Research Areas >> Neurological Disease
Target	IC50: 16 nM (DTG site of sigma receptor), 19 nM (PPP site of sigma receptor)[1] Ki: 4000 nM (Dopamine D2 receptor)[1]
In Vivo	Administration of Sigma-LIGAND-1 would reverse amphetamine-induced hyperlocomotion in mice, a behavioral model sensitive to antipsychotic compounds. Sigma-LIGAND-1 and its structural analogues have the potential antipsychotic activity[1].
References	[1]. Erickson RH, et al. (Aminoalkoxy)chromones. Selective sigma receptor ligands. J Med Chem. 1992 May 1;35(9):1526-35.

Molecular Formula	C₂₇H₃₃NO₄
Molecular Weight	435.56