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1631137-51-3

1631137-51-3 structure
1631137-51-3 structure
  • Name: E3 ligase Ligand 6
  • Chemical Name: E3 ligase Ligand 6
  • CAS Number: 1631137-51-3
  • Molecular Formula: C24H31F3N4O5S
  • Molecular Weight: 544.59
  • Catalog: Signaling Pathways PROTAC Ligand for E3 Ligase
  • Create Date: 2018-02-12 06:04:58
  • Modify Date: 2024-01-09 19:31:52
  • Protein degrader 1 TFA is a small molecule ligand for VHL, an E3 ligase which has been targeted in numerous PROTACs.

Name E3 ligase Ligand 6
Description Protein degrader 1 TFA is a small molecule ligand for VHL, an E3 ligase which has been targeted in numerous PROTACs.
Related Catalog
Target

E3 ligase VHL[1]

In Vitro Synthesis of HaloPROTACs contains Protein degrader 1 (Degradation Inducing Moiety A). Protein degrader 1 (Degradation Inducing Moiety A) is capable of inducing the degradation of GFP-HaloTag7 in cell-based assays. HaloPROTACs containing Protein degrader 1 (Degradation Inducing Moiety A) lead to nearly 70% degradation of GFP-HaloTag7, when sufficiently long linkers are used[1].
References

[1]. Buckley DL, et al. HaloPROTACS: Use of Small Molecule PROTACs to Induce Degradation of HaloTag Fusion Proteins. ACS Chem Biol. 2015 Aug 21;10(8):1831-7.

Molecular Formula C24H31F3N4O5S
Molecular Weight 544.59