E3 ligase Ligand 6

Modify Date: 2024-01-09 19:31:52

Use of E3 ligase Ligand 6

Protein degrader 1 TFA is a small molecule ligand for VHL, an E3 ligase which has been targeted in numerous PROTACs.

Name	E3 ligase Ligand 6

Description	Protein degrader 1 TFA is a small molecule ligand for VHL, an E3 ligase which has been targeted in numerous PROTACs.
Related Catalog	Signaling Pathways >> PROTAC >> Ligand for E3 Ligase Research Areas >> Cancer
Target	E3 ligase VHL[1]
In Vitro	Synthesis of HaloPROTACs contains Protein degrader 1 (Degradation Inducing Moiety A). Protein degrader 1 (Degradation Inducing Moiety A) is capable of inducing the degradation of GFP-HaloTag7 in cell-based assays. HaloPROTACs containing Protein degrader 1 (Degradation Inducing Moiety A) lead to nearly 70% degradation of GFP-HaloTag7, when sufficiently long linkers are used[1].
References	[1]. Buckley DL, et al. HaloPROTACS: Use of Small Molecule PROTACs to Induce Degradation of HaloTag Fusion Proteins. ACS Chem Biol. 2015 Aug 21;10(8):1831-7.

Molecular Formula	C₂₄H₃₁F₃N₄O₅S
Molecular Weight	544.59

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Price: $110/1mg

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