1638504-56-9

1638504-56-9 structure

Name: HIV-1 integrase inhibitor 3
Chemical Name: HIV-1 integrase inhibitor 3
CAS Number: 1638504-56-9
Molecular Formula: C₂₁H₂₂F₂N₄O₄
Molecular Weight: 432.42
Catalog: Signaling Pathways Anti-infection HIV
Create Date: 2018-02-25 09:35:12
Modify Date: 2024-01-14 10:47:54
HIV-1 integrase inhibitor 3 is a HIV-1 integrase strand transfer (INST) inhibitor with an IC50 of 2.7 nM.

Name	HIV-1 integrase inhibitor 3

Description	HIV-1 integrase inhibitor 3 is a HIV-1 integrase strand transfer (INST) inhibitor with an IC50 of 2.7 nM.
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> HIV Integrase Signaling Pathways >> Anti-infection >> HIV Research Areas >> Infection
Target	IC50: 2.7 nM (INST)[1]
In Vitro	HIV-1 integrase inhibitor 3 (compound 4c) is a HIV-1 integrase strand transfer (INST) inhibitor with an IC50 of 2.7 nM. HIV-1 integrase inhibitor 3 also displays an antiviral inhibitory potency against the Q148H/G140S mutant with an EC50 of 7 nM[1].
References	[1]. Zhao XZ, et al. HIV-1 Integrase Strand Transfer Inhibitors with Reduced Susceptibility to Drug Resistant MutantIntegrases. ACS Chem Biol. 2016 Apr 15;11(4):1074-81.