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1797406-80-4

1797406-80-4 structure

1797406-80-4 structure

Name: E3 ligase Ligand-Linker Conjugates 12
Chemical Name: E3 ligase Ligand-Linker Conjugates 12
CAS Number: 1797406-80-4
Molecular Formula: C₃₀H₄₃N₇O₇S
Molecular Weight: 645.77
Catalog: Signaling Pathways PROTAC E3 Ligase Ligand-Linker Conjugate
Create Date: 2018-06-05 10:24:11
Modify Date: 2024-01-14 16:54:44
E3 ligase Ligand-Linker Conjugates 12 is a synthesized compound that incorporates an E3 ligase ligand and a linker used in PROTAC technology.

Name	E3 ligase Ligand-Linker Conjugates 12

Description	E3 ligase Ligand-Linker Conjugates 12 is a synthesized compound that incorporates an E3 ligase ligand and a linker used in PROTAC technology.
Related Catalog	Signaling Pathways >> PROTAC >> E3 Ligase Ligand-Linker Conjugate Research Areas >> Cancer
Target	E3 Ligase Ligand-Linker Conjugate[1]
In Vitro	E3 ligase Ligand-Linker Conjugates 12 is extracted from patent WO/2016/146985A1, figure 11. PROTAC has been developed having structure A-L-B that can tether a bromodomain inhibitor via a moiety which binds to a protein within the bromo- and Extra-terminal (BET) family of proteins to a small molecule E3 ubiquintin ligase protein binding ligand compond via a suitable linker[1][2].
References	[1]. WO/2016/146985A1 [2]. Zengerle M, et al. Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4. ACS Chem Biol. 2015 Aug 21;10(8):1770-7.

Molecular Formula	C₃₀H₄₃N₇O₇S
Molecular Weight	645.77

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