E3 ligase Ligand-Linker Conjugates 12

Modify Date: 2024-01-14 16:54:44

E3 ligase Ligand-Linker Conjugates 12 Structure
E3 ligase Ligand-Linker Conjugates 12 structure
Common Name E3 ligase Ligand-Linker Conjugates 12
CAS Number 1797406-80-4 Molecular Weight 645.77
Density N/A Boiling Point N/A
Molecular Formula C30H43N7O7S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of E3 ligase Ligand-Linker Conjugates 12


E3 ligase Ligand-Linker Conjugates 12 is a synthesized compound that incorporates an E3 ligase ligand and a linker used in PROTAC technology.

 Names

Name E3 ligase Ligand-Linker Conjugates 12

 E3 ligase Ligand-Linker Conjugates 12 Biological Activity

Description E3 ligase Ligand-Linker Conjugates 12 is a synthesized compound that incorporates an E3 ligase ligand and a linker used in PROTAC technology.
Related Catalog
Target

E3 Ligase Ligand-Linker Conjugate[1]

In Vitro E3 ligase Ligand-Linker Conjugates 12 is extracted from patent WO/2016/146985A1, figure 11. PROTAC has been developed having structure A-L-B that can tether a bromodomain inhibitor via a moiety which binds to a protein within the bromo- and Extra-terminal (BET) family of proteins to a small molecule E3 ubiquintin ligase protein binding ligand compond via a suitable linker[1][2].
References

[1]. WO/2016/146985A1

[2]. Zengerle M, et al. Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4. ACS Chem Biol. 2015 Aug 21;10(8):1770-7.

 Chemical & Physical Properties

Molecular Formula C30H43N7O7S
Molecular Weight 645.77