188260-50-6

188260-50-6 structure

Name: BCR-ABL-IN-1
Chemical Name: BCR-ABL-IN-1
CAS Number: 188260-50-6
Molecular Formula: C₂₃H₂₁F₄N₅O
Molecular Weight: 459.44
Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK Bcr-Abl
Create Date: 2018-01-12 01:20:20
Modify Date: 2024-01-17 15:19:59
BCR-ABL-IN-1 is an inhibitor of BCR-ABL tyrosine kinase, with a pIC50 of 6.46, and may be used in the research of chronic myelogenous leukemia.

Name	BCR-ABL-IN-1

Description	BCR-ABL-IN-1 is an inhibitor of BCR-ABL tyrosine kinase, with a pIC50 of 6.46, and may be used in the research of chronic myelogenous leukemia.
Related Catalog	Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Bcr-Abl Research Areas >> Cancer
Target	pIC50: 6.46 (BCR-ABL)[1]
In Vitro	BCR-ABL-IN-1 (Compound 21) is an inhibitor of BCR-ABL tyrosine kinase, with a pIC50 of 6.46, and may be used in the research of chronic myelogenous leukemia.
References	[1]. Cui J1, et al. BCR-ABL tyrosine kinase inhibitor pharmacophore model derived from a series of phenylaminopyrimidine-based (PAP) derivatives. Bioorg Med Chem Lett. 2013 Apr 15;23(8):2442-50.