261766-73-8
261766-73-8 structure
- Name: 5-HT4 antagonist 1
- Chemical Name: 5-HT4 antagonist 1
- CAS Number: 261766-73-8
- Molecular Formula: C23H36N4O5S
- Molecular Weight: 480.62
- Catalog: Signaling Pathways GPCR/G Protein 5-HT Receptor
- Create Date: 2018-01-28 23:08:11
- Modify Date: 2024-01-09 11:51:14
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5-HT4 antagonist 1 is a 5-HT4 receptor antagonist with a pKi of 9.6.
| Name | 5-HT4 antagonist 1 |
|---|
| Description | 5-HT4 antagonist 1 is a 5-HT4 receptor antagonist with a pKi of 9.6. |
|---|---|
| Related Catalog | |
| Target |
pKI: 9.6 (5-HT4 receptor)[1] |
| In Vitro | 5-HT4 antagonist 1 (compound 6b) is a 5-HT4 receptor antagonist with a pKi of 9.6. |
| In Vivo | 5-HT4 antagonist 1 (compound 6b) demonstrates good exposure and prolongs t1/2 in other species, including the mouse (t1/2 7 h), rat (t1/2 12 h) and mini-pig (t1/2 21 h). In Phase I clinical trial, it is found that 5-HT4 antagonist 1 has good oral bioavailability with a steady state plasma t1/2 of >100 h[1]. |
| References |
| Molecular Formula | C23H36N4O5S |
|---|---|
| Molecular Weight | 480.62 |
| Storage condition | 2-8℃ |