1186195-59-4

1186195-59-4 structure

Name: Tocrifluor T1117
Chemical Name: T1117
CAS Number: 1186195-59-4
Molecular Formula: C₅₆H₅₃Cl₂N₇O₅
Molecular Weight: 974.970
Catalog: Signaling Pathways GPCR/G Protein Cannabinoid Receptor
Create Date: 2018-06-07 02:43:39
Modify Date: 2024-01-13 15:06:23
Tocrifluor 1117 (T1117), a fluorescent form of the cannabinoid CB1 receptor antagonist AM251, is a selective fluorescent GPR55 ligand. Tocrifluor 1117 is a potent tool for identifying the cellular location of cannabinoid receptors (including GPR55 in living tissues) (Ex/Em=543/590 nm)[1][2].

Name	T1117
Synonyms	1H-Pyrazole-3-carboxamide, 5-[4'-[3-[[[3',6'-bis(dimethylamino)-3-oxospiro[isobenzofuran-1(3H),9'-[9H]xanthen]-5-yl]carbonyl]amino]propyl][1,1'-biphenyl]-4-yl]-1-(2,4-dichlorophenyl)-4-methyl-N-1-piperidinyl- 5-{4'-[3-({[3',6'-Bis(dimethylamino)-3-oxo-3H-spiro[2-benzofuran-1,9'-xanthen]-5-yl]carbonyl}amino)propyl]biphenyl-4-yl}-1-(2,4-dichlorophenyl)-4-methyl-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide T1117 5-{4'-[3-({[3',6'-Bis(dimethylamino)-3-oxo-3H-spiro[2-benzofuran-1,9'-xanthen]-5-yl]carbonyl}amino)propyl]-4-biphenylyl}-1-(2,4-dichlorophenyl)-4-methyl-N-(1-piperidinyl)-1H-pyrazole-3-carboxamide

Description	Tocrifluor 1117 (T1117), a fluorescent form of the cannabinoid CB1 receptor antagonist AM251, is a selective fluorescent GPR55 ligand. Tocrifluor 1117 is a potent tool for identifying the cellular location of cannabinoid receptors (including GPR55 in living tissues) (Ex/Em=543/590 nm)[1][2].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> GPR55 Signaling Pathways >> GPCR/G Protein >> Cannabinoid Receptor
Target	CB1
References	[1]. Daly CJ, et al. Fluorescent ligand binding reveals heterogeneous distribution of adrenoceptors and 'cannabinoid-like' receptors in small arteries. Br J Pharmacol. 2010 Feb;159(4):787-96. [2]. Singh NS, et al. Selective GPR55 antagonism reduces chemoresistance in cancer cells. Pharmacol Res. 2016 Sep;111:757-766.