1591932-50-1

1591932-50-1 structure

Name: Bizine
Chemical Name: N-[4-(2-Hydrazinoethyl)phenyl]-4-phenylbutanamide dihydrochloride
CAS Number: 1591932-50-1
Molecular Formula: C₁₈H₂₅Cl₂N₃O
Molecular Weight: 370.317
Catalog: Signaling Pathways Epigenetics Histone Demethylase
Create Date: 2018-06-05 22:06:49
Modify Date: 2024-01-02 19:38:11
Bizine, a Phenelzine analogue, is a potent and selective LSD1 inhibitor, with a b>Ki of 59 nM. Bizine can modulate bulk histone methylation in cancer cells. Bizine shows neuroprotective effects[1].

Name	N-[4-(2-Hydrazinoethyl)phenyl]-4-phenylbutanamide dihydrochloride
Synonyms	Benzenebutanamide, N-[4-(2-hydrazinylethyl)phenyl]-, hydrochloride (1:2) N-[4-(2-Hydrazinoethyl)phenyl]-4-phenylbutanamide dihydrochloride

Description	Bizine, a Phenelzine analogue, is a potent and selective LSD1 inhibitor, with a b>Ki of 59 nM. Bizine can modulate bulk histone methylation in cancer cells. Bizine shows neuroprotective effects[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Epigenetics >> Histone Demethylase Research Areas >> Neurological Disease
Target	Ki: 59 nM (LSD1)[1]
References	[1]. Prusevich P, et, al. A selective phenelzine analogue inhibitor of histone demethylase LSD1. ACS Chem Biol. 2014 Jun 20;9(6):1284-93.