1008402-47-8

1008402-47-8 structure

Name: Bis-Mal-PEG3
Chemical Name: N,N'-[Oxybis(2,1-ethanediyloxy-2,1-ethanediyl)]bis[3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanamide]
CAS Number: 1008402-47-8
Molecular Formula: C₂₂H₃₀N₄O₉
Molecular Weight: 494.495
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2018-06-24 17:23:59
Modify Date: 2024-01-09 17:45:50
Bis-Mal-PEG3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	N,N'-[Oxybis(2,1-ethanediyloxy-2,1-ethanediyl)]bis[3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanamide]
Synonyms	N,N'-[Oxybis(2,1-ethanediyloxy-2,1-ethanediyl)]bis[3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanamide] 1H-Pyrrole-1-propanamide, N,N'-[oxybis(2,1-ethanediyloxy-2,1-ethanediyl)]bis[2,5-dihydro-2,5-dioxo-

Description	Bis-Mal-PEG3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562