1011244-72-6

1011244-72-6 structure

Name: Teriflunomide impurity 3
Chemical Name: 4-Amino-N-[4-(trifluoromethyl)phenyl]benzamide
CAS Number: 1011244-72-6
Molecular Formula: C₁₄H₁₁F₃N₂O
Molecular Weight: 280.245
Catalog: Signaling Pathways Immunology/Inflammation COX
Create Date: 2018-06-28 02:02:48
Modify Date: 2024-01-14 13:29:24
Teriflunomide impurity 3 (4-Amino-N-(4-trifluoromethylphenyl)benzamide) is a selective COX-1 inhibitor with an IC50 of 30 µM. Teriflunomide impurity 3 is less active against COX-2 (IC50>100 µM)[1].

Name	4-Amino-N-[4-(trifluoromethyl)phenyl]benzamide
Synonyms	Benzamide, 4-amino-N-[4-(trifluoromethyl)phenyl]- 4-Amino-N-[4-(trifluoromethyl)phenyl]benzamide

Description	Teriflunomide impurity 3 (4-Amino-N-(4-trifluoromethylphenyl)benzamide) is a selective COX-1 inhibitor with an IC50 of 30 µM. Teriflunomide impurity 3 is less active against COX-2 (IC50>100 µM)[1].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> Immunology/Inflammation >> COX
Target	COX-1:30 μM (IC50)
In Vitro	Teriflunomide impurity 3 (4-Amino-N-(4-trifluoromethylphenyl)benzamide; compound 11q) is an amide-bond-reversed compound bearing trifluoromethyl and amino substituents showed potent COX-1-selective inhibitory activity[1].
References	[1]. Hiroki Kakuta, et al. Cyclooxygenase-1-selective inhibitors are attractive candidates for analgesics that do not cause gastric damage. design and in vitro/in vivo evaluation of a benzamide-type cyclooxygenase-1 selective inhibitor. J Med Chem. 2008 Apr 24;51(8):2400-11.