1051375-13-3

1051375-13-3 structure

Name: Cabotegravir Sodium
Chemical Name: CABOTEGRAVIR SODIUM
CAS Number: 1051375-13-3
Molecular Formula: C₁₉H₁₆F₂N₃NaO₅
Molecular Weight: 427.334
Catalog: Signaling Pathways Metabolic Enzyme/Protease HIV Integrase
Create Date: 2018-07-18 02:16:14
Modify Date: 2024-01-02 11:47:40
Cabotegravir sodium is a highly potent HIV integrase inhibitor with an IC50 value of 2.5 nM for HIVADA. Cabotegravir sodium is primarily metabolized by uridine diphosphate glucuronosyltransferase (UGT) 1A1, with low potential to interact with other antiretroviral drugs (ARVs)[1].

Name	CABOTEGRAVIR SODIUM
Synonyms	S-265744B Oxazolo[3,2-a]pyrido[1,2-d]pyrazine-8-carboxamide, N-[(2,4-difluorophenyl)methyl]-2,3,5,7,11,11a-hexahydro-6-hydroxy-3-methyl-5,7-dioxo-, sodium salt, (3S,11aR)- (1:1) 3L12PT535M CABOTEGRAVIR SODIUM Sodium (3S,11aR)-8-[(2,4-difluorobenzyl)carbamoyl]-3-methyl-5,7-dioxo-2,3,5,7,11,11a-hexahydro[1,3]oxazolo[3,2-a]pyrido[1,2-d]pyrazin-6-olate GSK1265744B

Description	Cabotegravir sodium is a highly potent HIV integrase inhibitor with an IC50 value of 2.5 nM for HIVADA. Cabotegravir sodium is primarily metabolized by uridine diphosphate glucuronosyltransferase (UGT) 1A1, with low potential to interact with other antiretroviral drugs (ARVs)[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Metabolic Enzyme/Protease >> HIV Integrase
Target	IC50: 2.5 nM (HIVADA)[1]
References	[1]. Zhou T, et al. Creation of a nanoformulated cabotegravir prodrug with improved antiretroviral profiles. Biomaterials. 2018 Jan;151:53-65.