172152-50-0
172152-50-0 structure
- Name: Ilaprazole sodium
- Chemical Name: Sodium 2-{[(4-methoxy-3-methyl-2-pyridinyl)methyl]sulfinyl}-6-(1H-pyrrol-1-yl)benzimidazol-1-ide
- CAS Number: 172152-50-0
- Molecular Formula: C19H17N4NaO2S
- Molecular Weight: 388.419
- Catalog: Signaling Pathways Cell Cycle/DNA Damage TOPK
- Create Date: 2018-06-17 14:32:57
- Modify Date: 2024-01-02 15:28:48
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Ilaprazole (IY-81149) sodium is an orally active proton pump inhibitor. Ilaprazole sodium irreversibly inhibits H+/K+-ATPase in a dose-dependent manner with an IC50 of 6 μM in rabbit parietal cell preparation. Ilaprazole sodium is used for the research of gastric ulcers. Ilaprazole sodium is also a potent TOPK (T-lymphokine-activated killer cell-originated protein kinase) inhibitor[1][2].
| Name | Sodium 2-{[(4-methoxy-3-methyl-2-pyridinyl)methyl]sulfinyl}-6-(1H-pyrrol-1-yl)benzimidazol-1-ide |
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| Synonyms |
1H-Benzimidazole, 2-[[(4-methoxy-3-methyl-2-pyridinyl)methyl]sulfinyl]-6-(1H-pyrrol-1-yl)-, sodium salt (1:1)
Sodium 2-{[(4-methoxy-3-methyl-2-pyridinyl)methyl]sulfinyl}-6-(1H-pyrrol-1-yl)benzimidazol-1-ide |
| Description | Ilaprazole (IY-81149) sodium is an orally active proton pump inhibitor. Ilaprazole sodium irreversibly inhibits H+/K+-ATPase in a dose-dependent manner with an IC50 of 6 μM in rabbit parietal cell preparation. Ilaprazole sodium is used for the research of gastric ulcers. Ilaprazole sodium is also a potent TOPK (T-lymphokine-activated killer cell-originated protein kinase) inhibitor[1][2]. |
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| Related Catalog | |
| In Vitro | On cumulation of 14C-aminopyrine in histamine stimulated parietal cells, the IC50 of Ilaprazole (IY-81149) sodium is 9 nM[1]. |
| In Vivo | Ilaprazole sodium (3-30 mg/kg; i.d.) dose-dependently inhibits gastric acid secretion[1]. In anesthetized rats, Ilaprazole sodium dose-dependently increases gastric pH which is lowered by histamine infusion. In the case of i.v. injection, the ED50 of Ilaprazole sodium and Omeprazole is 1.2 and 1.4 mg/kg and in the case of i.d. administration, the ED50 of Ilaprazole sodium and omeprazole is 3.9 and 4.1 mg/kg, respectively. Ilaprazole sodium also significantly inhibits pentagastrin-stimulated gastric secretion. Its ED50 is 2.1 mg/kg and that of Omeprazole was 3.5 mg/kg with i.d. administration. In the case of i.v. injection, Ilaprazole sodium is equipotent to Omeprazole. Ilaprazole sodium also inhibits gastric acid secretion strongly in fistular rats. The ED50 of Ilaprazole sodium administered intraduodenally is 0.43 mg/kg and that of omeprazole Is 0.68 mg/kg[1]. Animal Model: Male SD rat (after pylorus ligation)[1] Dosage: 3, 10, 30 mg/kg Administration: Intraduodenally Result: The acid output and volume significantly inhibited by about 60 % and 46 % at 3 mg/kg were s, respectively. At 30 mg/kg, it showed 93 % and 73 % inhibition on acid output and volume, respectively. |
| References |
| Molecular Formula | C19H17N4NaO2S |
|---|---|
| Molecular Weight | 388.419 |
| Exact Mass | 388.096985 |
| Storage condition | -20℃ |