1334170-03-4

1334170-03-4 structure

Name: Fmoc-NH-PEG8-NHS ester
Chemical Name: 9H-Fluoren-9-ylmethyl {27-[(2,5-dioxo-1-pyrrolidinyl)oxy]-27-oxo-3,6,9,12,15,18,21,24-octaoxaheptacos-1-yl}carbamate
CAS Number: 1334170-03-4
Molecular Formula: C₃₈H₅₂N₂O₁₄
Molecular Weight: 760.825
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2018-07-02 04:53:12
Modify Date: 2024-01-04 09:10:39
Fmoc-NH-PEG8-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	9H-Fluoren-9-ylmethyl {27-[(2,5-dioxo-1-pyrrolidinyl)oxy]-27-oxo-3,6,9,12,15,18,21,24-octaoxaheptacos-1-yl}carbamate
Synonyms	9H-Fluoren-9-ylmethyl {27-[(2,5-dioxo-1-pyrrolidinyl)oxy]-27-oxo-3,6,9,12,15,18,21,24-octaoxaheptacos-1-yl}carbamate Carbamic acid, N-[27-[(2,5-dioxo-1-pyrrolidinyl)oxy]-27-oxo-3,6,9,12,15,18,21,24-octaoxaheptacos-1-yl]-, 9H-fluoren-9-ylmethyl ester

Description	Fmoc-NH-PEG8-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs Alkyl/ether
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562