1446282-18-3

1446282-18-3 structure
1446282-18-3 structure
  • Name: Amino-PEG5-Boc
  • Chemical Name: 2-Methyl-2-propanyl 1-amino-3,6,9,12,15-pentaoxaoctadecan-18-oate
  • CAS Number: 1446282-18-3
  • Molecular Formula: C17H35NO7
  • Molecular Weight: 365.462
  • Catalog: Signaling Pathways PROTAC PROTAC Linker
  • Create Date: 2018-06-26 10:19:49
  • Modify Date: 2024-01-10 21:03:21
  • Amino-PEG5-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name 2-Methyl-2-propanyl 1-amino-3,6,9,12,15-pentaoxaoctadecan-18-oate
Synonyms 2-Methyl-2-propanyl 1-amino-3,6,9,12,15-pentaoxaoctadecan-18-oate
3,6,9,12,15-Pentaoxaoctadecan-18-oic acid, 1-amino-, 1,1-dimethylethyl ester
MFCD25424125
Amino-PEG6-t-butyl ester
Amino-PEG5-t-butyl ester
Description Amino-PEG5-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

Alkyl/ether

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Density 1.0±0.1 g/cm3
Boiling Point 439.1±40.0 °C at 760 mmHg
Molecular Formula C17H35NO7
Molecular Weight 365.462
Flash Point 114.1±23.7 °C
Exact Mass 365.241364
LogP -0.59
Vapour Pressure 0.0±1.1 mmHg at 25°C
Index of Refraction 1.457
Hazard Codes Xn
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