1185049-09-5

1185049-09-5 structure

Name: Flumequine-13C3
Chemical Name: 9-Fluoro-5-methyl-1-oxo(1,2-13C2)-6,7-dihydro-1H,5H-pyrido[3,2,1-ij]quinoline-2-(13C)carboxylic acid
CAS Number: 1185049-09-5
Molecular Formula: C₁₁₁₃C₃H₁₂FNO₃
Molecular Weight: 264.226
Catalog: analytical chemistry Standard Forensic and veterinary standards
Create Date: 2018-06-28 21:36:59
Modify Date: 2024-01-09 19:30:29
Flumequine-13C3 is the 13C3 labeled Flumequine. Flumequine (R-802) is a quinolone antibiotic, and acts as a topoisomerase II inhibitor, with an IC50 of 15 μM (3.92 μg/mL).

Name	9-Fluoro-5-methyl-1-oxo(1,2-13C2)-6,7-dihydro-1H,5H-pyrido[3,2,1-ij]quinoline-2-(13C)carboxylic acid
Synonyms	9-Fluoro-5-methyl-1-oxo(1,2-13C2)-6,7-dihydro-1H,5H-pyrido[3,2,1-ij]quinoline-2-(13C)carboxylic acid 1H,5H-Benzo[ij]quinolizine-1,2-13C2-2-carboxylic-13C acid, 9-fluoro-6,7-dihydro-5-methyl-1-oxo-

Description	Flumequine-13C3 is the 13C3 labeled Flumequine. Flumequine (R-802) is a quinolone antibiotic, and acts as a topoisomerase II inhibitor, with an IC50 of 15 μM (3.92 μg/mL).
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-223. [2]. Kashida Y, et al. Mechanistic study on flumequine hepatocarcinogenicity focusing on DNA damage in mice. Toxicol Sci. 2002 Oct;69(2):317-21. [3]. Aller-Morán LM, et al. Evaluation of the in vitro activity of flumequine against field isolates of Brachyspira hyodysenteriae. Res Vet Sci. 2015 Dec;103:51-3. [4]. Giraud E, et al. Mechanisms of quinolone resistance and clonal relationship among Aeromonas salmonicida strains isolated from reared fish with furunculosis. J Med Microbiol. 2004 Sep;53(Pt 9):895-901.

RIDADR	NONH for all modes of transport