1276297-68-7

1276297-68-7 structure

Name: Thiorphan-d7
Chemical Name: N-[3-(2H5)Phenyl-2-(sulfanylmethyl)(3,3-2H2)propanoyl]glycine
CAS Number: 1276297-68-7
Molecular Formula: C₁₂H₈D₇NO₃S
Molecular Weight: 260.361
Catalog: Signaling Pathways Metabolic Enzyme/Protease Neprilysin
Create Date: 2018-07-20 01:53:33
Modify Date: 2024-01-02 19:31:55
Thiorphan-d7 is the deuterium labeled Thiorphan[1]. Thiorphan is a selective NEP (neprilysin) inhibitor with an IC50 of 6.9 nM[2].

Name	N-[3-(2H5)Phenyl-2-(sulfanylmethyl)(3,3-2H2)propanoyl]glycine
Synonyms	N-[3-(2H5)Phenyl-2-(sulfanylmethyl)(3,3-2H2)propanoyl]glycine Glycine, N-[2-(mercaptomethyl)-1-oxo-3-(phenyl-d5)propyl-3,3-d2]-

Description	Thiorphan-d7 is the deuterium labeled Thiorphan[1]. Thiorphan is a selective NEP (neprilysin) inhibitor with an IC50 of 6.9 nM[2].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> Metabolic Enzyme/Protease >> Neprilysin
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [2]. Whyteside AR, Turner AJ. Human neprilysin-2 (NEP2) and NEP display distinct subcellular localisations and substrate preferences. FEBS Lett. 2008 Jul 9;582(16):2382-6.