1793050-70-0

1793050-70-0 structure

Name: (R)-Gyramide A hydrochloride
Chemical Name: 5-Fluoro-N-[(3R)-1-(4-isopropoxybenzyl)-3-pyrrolidinyl]-2-methylbenzenesulfonamide hydrochloride (1:1)
CAS Number: 1793050-70-0
Molecular Formula: C₂₁H₂₈ClFN₂O₃S
Molecular Weight: 442.975
Create Date: 2018-06-17 03:07:23
Modify Date: 2025-09-09 19:46:22
(R)-Gyramide A hydrochloride is a bacterial DNA gyrase inhibitor that disrupts supercoiling activity with an IC50 value of 3.3 µM. (R)-Gyramide A hydrochloride demonstrates antibacterial activity against E. coli, P. aeruginosa, and S. enterica (MICs of 10-80 µM). (R)-Gyramide A hydrochloride does not affect the closely related enzyme topoisomerase IV.

Name	5-Fluoro-N-[(3R)-1-(4-isopropoxybenzyl)-3-pyrrolidinyl]-2-methylbenzenesulfonamide hydrochloride (1:1)
Synonyms	5-Fluoro-N-[(3R)-1-(4-isopropoxybenzyl)-3-pyrrolidinyl]-2-methylbenzenesulfonamide hydrochloride (1:1) Benzenesulfonamide, 5-fluoro-2-methyl-N-[(3R)-1-[[4-(1-methylethoxy)phenyl]methyl]-3-pyrrolidinyl]-, hydrochloride (1:1)

Description	(R)-Gyramide A hydrochloride is a bacterial DNA gyrase inhibitor that disrupts supercoiling activity with an IC50 value of 3.3 µM. (R)-Gyramide A hydrochloride demonstrates antibacterial activity against E. coli, P. aeruginosa, and S. enterica (MICs of 10-80 µM). (R)-Gyramide A hydrochloride does not affect the closely related enzyme topoisomerase IV.