227803-63-6

227803-63-6 structure

Name: Aclerastide
Chemical Name: aclerastide
CAS Number: 227803-63-6
Molecular Formula: C₄₂H₆₄N₁₂O₁₁
Molecular Weight: 913.031
Catalog: Signaling Pathways GPCR/G Protein Angiotensin Receptor
Create Date: 2018-10-17 13:04:45
Modify Date: 2024-01-06 20:25:59
Aclerastide (DSC-127) is an angiotensin receptor agonist. Aclerastide also is a peptide analog of angiotensin II. Aclerastide can be used for the research of tissue regeneration in diabetic ulcers[1][2].

Name	aclerastide
Synonyms	[3-(L-2-aminohexanoic acid)]angiotensin II-(1-7)-peptide aclerastide L-Proline, L-α-aspartyl-N5-(diaminomethylene)-L-ornithyl-L-norleucyl-L-tyrosyl-L-isoleucyl-L-histidyl- L-α-Aspartyl-L-arginyl-L-norleucyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-proline UNII:YYD6UT8T47

Description	Aclerastide (DSC-127) is an angiotensin receptor agonist. Aclerastide also is a peptide analog of angiotensin II. Aclerastide can be used for the research of tissue regeneration in diabetic ulcers[1][2].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> GPCR/G Protein >> Angiotensin Receptor
In Vivo	Aclerastide (0.1 mg/wound; day for 5 days) shows superior efficacy in the db/db mouse model of wound healing[1]. Aclerastide (topically administered; 100 μL; once a day; for 14 days) elevates levels of reactive oxygen species and of active MMP-9[2]. Animal Model: db/db mice[2] Dosage: 100 μL Administration: Topically administered, once a day, for 14 days Result: Upregulated reactive oxygen species during inflammation. Increased the levels of the detrimental active MMP-9 in diabetic wounds.